| STRA6 |
Human |
Matthew-Wood sindrome: outflow tract-atrial and ventricular septal defects |
(Golzio et al., 2007; Pasutto et al., 2007) |
| Zebrafish |
Aberrant heart-reminiscent of increased RA signaling |
(Isken et al., 2008) |
| DHRS3 |
Mouse |
Outflow tract and septal defects |
(Billings et al., 2013) |
| RDH10 |
Mouse |
Looping defects, enlarged hearts, and edema |
(Sandell et al., 2012) |
| ALDH1A2 |
Mouse |
Looping defects, enlarged hearts, edema, increased cardiomyocyte specification |
(Niederreither et al., 1999; Ryckebusch et al., 2008; Sirbu et al., 2008) |
| Zebrafish |
Enlarged hearts due to increased cardiomyocyte specification |
(Keegan et al., 2005) |
| CYP26A1 |
Human |
DiGeorge and Klippel-feil; Outflow tract defects |
(Pennimpede et al., 2010) |
| Mouse |
Gross aberrant cardiac defects including looping defects |
(Abu et al., 2001; Emoto et al., 2005; Ribes et al., 2007) |
| CYP26A1; CYP26C1 |
Mouse |
Gross aberrant cardiac defects including looping defects |
(Uehara et al., 2007) |
| Zebrafish |
Abnormal heart with increased atrial CMs |
(Rydeen et al., 2014) |
| RARa2 |
Chicken |
Defects in cardiac inflow tract |
(Romeih et al., 2003) |
| RARγ |
Chicken |
Defects in asymmetric orientation and looping morphogenesis |
(Romeih et al., 2003) |
| RARal; RARβ |
Mouse |
Outflow tract and aortic arch abnormalities; persistent truncus arteriousus; dextroposed aorta; high ventricular septal defects; abnormal aortic arch pattern. |
(Mendelsohn et al., 1994; Li et al., 2010) |
| RARal; RARγ |
| RARab1 |
Zebrafish |
Enlarged hearts with increased cardiomyocyte specification |
(D’Aniello et al.,2013) |
