Skip to main content
. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Clin Trials. 2014 Oct 27;12(1):24–33. doi: 10.1177/1740774514555585

Figure 3.

Figure 3

Comparison of operating characteristics computed via likelihood method and ‘3+3’derived probabilities. Likelihood probabilities are calculated for k = 4, under hypotheses H1(p1) : unsafe dose; H2(p2) : acceptable dose.

Likelihood Method: Weak Evid: P(weak evidence | true DLT);

Fav. H2 Lik: P(favors H2 | true DLT); Fav. H1 Lik: P(favors H1 | true DLT).

Algorithm: Fav. H2 Alg: P(escalation | true DLT); Fav. H1 Alg: P(non-escalation | true DLT).

(A): p1 = 0.40, p2 = 0.15 (B): p1 = 0.30, p2 = 0.05

(C): p1 = 0.15, p2 = 0.05 (D): p1 = 0.50, p2 = 0.30