Skip to main content
. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Clin Trials. 2014 Oct 27;12(1):24–33. doi: 10.1177/1740774514555585

Table 5.

Levels of evidence for determining if a dose is acceptable or toxic based on (p1 = 0.40, p2 = 0.15) and k = 2, 4. Numbers in cells are likelihood-ratios with colors indicating level of evidence. Dark/light green cells indicate evidence of acceptable dose; red/pink cells indicate evidence of toxic dose; gray cells indicate weak evidence. Dark green cells: LR ≥ 4; light green cells: 2 ≤ LR < 4; gray cells: 1/2 < LR < 2; pink cells: 1/4 < LR ≤ 1/2; red cells: LR ≤ 1/4.

Number of patients treated at dose j

Number of toxicities at dose j 1 2 3 4 5 6 7 8 9
0 1.42 2.01 2.84 4.03 5.71 8.08 11.45 16.22 22.98
1 0.38 0.53 0.75 1.07 1.51 2.14 3.03 4.29 6.08
2 0.14 0.20 0.28 0.40 0.57 0.80 1.14 1.61
3 0.05 0.07 0.11 0.15 0.21 0.30 0.43
4 0.02 0.03 0.04 0.06 0.08 0.11
5 0.01 0.01 0.01 0.02 0.03
6 <0.01 <0.01 0.01 0.01