Skip to main content
. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Biochim Biophys Acta. 2014 Sep 28;1853(4):775–780. doi: 10.1016/j.bbamcr.2014.09.019

Figure 2. Model of MHC-II-Invariant chain complex-dependent pMHC-II concentration in lipid rafts.

Figure 2

Two MHC-II αβ-Ii nonameric complexes are present in an ILV-derived lipid raft microdomain (surrounded by the red border) containing large amounts of “relevant” antigenic peptides (indicated in yellow, left panel). Following Ii degradation, six MHC-II αβ-CLIP complexes are present in this same microdomain (center panel). Following CLIP removal by HLA-DM, six MHC-II αβ-peptide complexes are formed that are enriched in “relevant” antigenic peptides (in yellow) that are all present within a single membrane microdomain (right panel).

HHS Vulnerability Disclosure