Table 3.
Biological pathways associated with BPD or death, as compared to survivors without BPD. Pathways from the annotated gene sets of the molecular signatures database at the Broad Institute (http://www.broadinstitute.org/gsea/msigdb/index.jsp) are listed in order of increasing false discovery rate (FDR). Only pathways with FDR ≤0.1 are shown.
| Pathway Names | P values | FDR |
|---|---|---|
| GACAATC,MIR-219 | 1.41E-08 | 9.52E-05 |
| NUCLEAR_UBIQUITIN_LIGASE_COMPLEX | 2.16E-07 | 0.00073 |
| YRCCAKNNGNCGC_UNKNOWN | 7.11E-07 | 0.0016 |
| V$E2F_Q2 | 9.88E-07 | 0.001668 |
| NEURON_PROJECTION | 1.37E-05 | 0.015893 |
| V$GABP_B | 1.41E-05 | 0.015893 |
| TOMLINS_METASTASIS_DN | 1.66E-05 | 0.015965 |
| JAEGER_METASTASIS_UP | 3.34E-05 | 0.018801 |
| NUCLEOBASENUCLEOSIDENUCLEOTIDE_KIN ASE_ACTIVITY |
2.74E-05 | 0.018801 |
| RUIZ_TNC_TARGETS_DN | 2.99E-05 | 0.018801 |
| SUGAR_BINDING | 2.71E-05 | 0.018801 |
| V$E2F_Q4 | 3.27E-05 | 0.018801 |
| CARBOHYDRATE_BINDING | 4.87E-05 | 0.024581 |
| UBIQUITIN_LIGASE_COMPLEX | 5.10E-05 | 0.024581 |
| V$E2F_Q6 | 5.64E-05 | 0.025396 |
| LIPID_KINASE_ACTIVITY | 6.62E-05 | 0.027946 |
| V$FREAC7_01 | 7.88E-05 | 0.031284 |
| CAGCTTT,MIR-320 | 0.000106 | 0.033841 |
| DAZARD_RESPONSE_TO_UV_NHEK_UP | 0.000101 | 0.033841 |
| HALMOS_CEBPA_TARGETS_DN | 9.54E-05 | 0.033841 |
| MOREAUX_MULTIPLE_MYELOMA_BY_TACI_ UP |
0.00011 | 0.033841 |
| TAGHAVI_NEOPLASTIC_TRANSFORMATION | 0.000107 | 0.033841 |
| COLLER_MYC_TARGETS_UP | 0.000116 | 0.034047 |
| V$AML_Q6 | 0.000138 | 0.038786 |
| REACTOME_CALCITONIN_LIKE_LIGAND_RE CEPTORS |
0.00017 | 0.045858 |
| AMIT_EGF_RESPONSE_480_HELA | 0.000182 | 0.04725 |
| BIOCARTA_CTCF_PATHWAY | 0.000253 | 0.047743 |
| BIOCARTA_RAC1_PATHWAY | 0.0002 | 0.047743 |
| CTCTATG,MIR-368 | 0.000226 | 0.047743 |
| GNF2_SPINK1 | 0.000219 | 0.047743 |
| IIZUKA_LIVER_CANCER_PROGRESSION_L0_L 1_UP |
0.000242 | 0.047743 |
| IVANOVA_HEMATOPOIESIS_LATE_PROGENIT OR |
0.000263 | 0.047743 |
| module_320 | 0.000223 | 0.047743 |
| MUELLER_COMMON_TARGETS_OF_AML_FU SIONS_DN |
0.000246 | 0.047743 |
| REACTOME_ACTIVATION_OF_NMDA_RECEP | 0.000263 | 0.047743 |
| TOR_UPON_GLUTAMATE_BINDING_AND_PO STSYNAPTIC_EVENTS |
||
| RESPONSE_TO_STEROID_HORMONE_STIMUL US |
0.000269 | 0.047743 |
| SCGGAAGY_V$ELK1_02 | 0.000241 | 0.047743 |
| V$E47_01 | 0.000207 | 0.047743 |
| CELLULAR_BIOSYNTHETIC_PROCESS | 0.000294 | 0.048217 |
| DAZARD_RESPONSE_TO_UV_SCC_DN | 0.000296 | 0.048217 |
| REGULATION_OF_CELLULAR_PROTEIN_MET ABOLIC_PROCESS |
0.0003 | 0.048217 |
| V$ZF5_01 | 0.000283 | 0.048217 |
| GAGACTG,MIR-452 | 0.000334 | 0.050215 |
| KAPOSI_LIVER_CANCER_POOR_SURVIVAL_U P |
0.000342 | 0.050215 |
| MORF_BRCA1 | 0.00034 | 0.050215 |
| PACHER_TARGETS_OF_IGF1_AND_IGF2_UP | 0.000341 | 0.050215 |
| chr4q26 | 0.000363 | 0.052097 |
| BIOCARTA_MCM_PATHWAY | 0.000395 | 0.054476 |
| GGCACAT,MIR-455 | 0.000391 | 0.054476 |
| BEGUM_TARGETS_OF_PAX3_FOXO1_FUSION _UP |
0.000423 | 0.056037 |
| SENESE_HDAC1_AND_HDAC2_TARGETS_DN | 0.000415 | 0.056037 |
| CTCNANGTGNY_UNKNOWN | 0.000445 | 0.056717 |
| REGULATION_OF_PROTEIN_METABOLIC_PR OCESS |
0.000437 | 0.056717 |
| BIOCARTA_RAS_PATHWAY | 0.000475 | 0.057752 |
| chr10q23 | 0.000468 | 0.057752 |
| module_321 | 0.00048 | 0.057752 |
| V$NRF2_01 | 0.000488 | 0.057752 |
| KENNY_CTNNB1_TARGETS_DN | 0.000518 | 0.060337 |
| chr2q13 | 0.000568 | 0.064501 |
| REGULATION_OF_CELL_CYCLE | 0.000573 | 0.064501 |
| GNF2_SERPINI2 | 0.000604 | 0.066831 |
| V$T3R_Q6 | 0.00066 | 0.071888 |
| ACCGAGC,MIR-423 | 0.000686 | 0.073179 |
| HELLER_HDAC_TARGETS_UP | 0.000694 | 0.073179 |
| LEE_DIFFERENTIATING_T_LYMPHOCYTE | 0.000712 | 0.073942 |
| CHESLER_BRAIN_HIGHEST_EXPRESSION | 0.00079 | 0.080012 |
| MATSUDA_NATURAL_KILLER_DIFFERENTIA TION |
0.000794 | 0.080012 |
| MICROTUBULE_MOTOR_ACTIVITY | 0.000807 | 0.080139 |
| AGGGCCA,MIR-328 | 0.000836 | 0.081055 |
| HOFMANN_CELL_LYMPHOMA_DN | 0.000841 | 0.081055 |
| CYTOSKELETAL_PART | 0.000873 | 0.082976 |
| CYTOSKELETON | 0.00092 | 0.085062 |
| OHM_EMBRYONIC_CARCINOMA_UP | 0.000909 | 0.085062 |
| CAGCCTC,MIR-485-5P | 0.000934 | 0.085164 |
| PROTEIN_UBIQUITINATION | 0.000992 | 0.089296 |
| chr9q22 | 0.001106 | 0.096946 |
| FERREIRA_EWINGS_SARCOMA_UNSTABLE_V S_STABLE_DN |
0.001105 | 0.096946 |