Table 4.
Biological pathways associated with severe BPD or death, as compared to survivors without severe BPD. Pathways from the annotated gene sets of the molecular signatures database at the Broad Institute (http://www.broadinstitute.org/gsea/msigdb/index.jsp) are listed in order of increasing false discovery rate (FDR). Only pathways with FDR ≤0.1 are shown.
| Pathway Names | P values | FDR |
|---|---|---|
| PHOSPHORUS_OXYGEN_LYASE_ACTIVITY | 5.68E-08 | 0.000192 |
| CYCLASE_ACTIVITY | 4.57E-08 | 0.000192 |
| GNF2_PRDX2 | 2.16E-07 | 0.000487 |
| MORF_RAP1A | 6.18E-07 | 0.001043 |
| KUMAMOTO_RESPONSE_TO_NUTLIN_3A_UP | 1.87E-06 | 0.002526 |
| MITOCHONDRION | 2.73E-06 | 0.003076 |
| SHEDDEN_LUNG_CANCER_POOR_SURVIVAL _A6 |
3.48E-06 | 0.003357 |
| VALK_AML_CLUSTER_2 | 5.04E-06 | 0.003783 |
| GLUCOSE_CATABOLIC_PROCESS | 4.73E-06 | 0.003783 |
| REACTOME_TRANSMISSION_ACROSS_CHEMI CAL_SYNAPSES |
6.68E-06 | 0.00435 |
| BIOCARTA_CCR5_PATHWAY | 7.09E-06 | 0.00435 |
| GRAHAM_CML_DIVIDING_VS_NORMAL_QUI ESCENT_UP |
1.09E-05 | 0.006114 |
| MORF_BRCA1 | 1.35E-05 | 0.006995 |
| MAP_KINASE_ACTIVITY | 3.16E-05 | 0.009928 |
| REACTOME_NOREPINEPHRINE_NEUROTRAN SMITTER_RELEASE_CYCLE |
3.12E-05 | 0.009928 |
| KCCGNSWTTT_UNKNOWN | 3.24E-05 | 0.009928 |
| RESPONSE_TO_ENDOGENOUS_STIMULUS | 2.73E-05 | 0.009928 |
| DELAYED_RECTIFIER_POTASSIUM_CHANNE L_ACTIVITY |
2.79E-05 | 0.009928 |
| module_428 | 2.35E-05 | 0.009928 |
| MORF_ATRX | 2.86E-05 | 0.009928 |
| TAGCTTT,MIR-9 | 3.21E-05 | 0.009928 |
| REACTOME_CLASS_C3_METABOTROPIC_GLU TAMATE_PHEROMONE_RECEPTORS |
2.80E-05 | 0.009928 |
| RESPONSE_TO_DNA_DAMAGE_STIMULUS | 3.54E-05 | 0.010382 |
| TOMLINS_PROSTATE_CANCER_UP | 4.63E-05 | 0.012494 |
| MCCLUNG_DELTA_FOSB_TARGETS_2WK | 4.48E-05 | 0.012494 |
| TRANSCRIPTION_COACTIVATOR_ACTIVITY | 5.68E-05 | 0.014751 |
| RODRIGUES_NTN1_AND_DCC_TARGETS | 6.01E-05 | 0.015023 |
| V$CREB_02 | 6.67E-05 | 0.016079 |
| GCM_GSPT1 | 7.38E-05 | 0.017173 |
| FERRARI_RESPONSE_TO_FENRETINIDE_DN | 8.00E-05 | 0.017994 |
| ATAAGCT,MIR-21 | 8.47E-05 | 0.018436 |
| NAKAMURA_CANCER_MICROENVIRONMENT _DN |
9.69E-05 | 0.020443 |
| LEE_INTRATHYMIC_T_PROGENITOR | 0.00011 | 0.022509 |
| TCCCCAC,MIR-491 | 0.000128 | 0.025452 |
| CYTOSOLIC_PART | 0.000133 | 0.025637 |
| WINTER_HYPOXIA_UP | 0.000169 | 0.029972 |
| TRANSCRIPTION_ACTIVATOR_ACTIVITY | 0.000162 | 0.029972 |
| MOREAUX_MULTIPLE_MYELOMA_BY_TACI_ UP |
0.000165 | 0.029972 |
| NELSON_RESPONSE_TO_ANDROGEN_UP | 0.000179 | 0.030963 |
| PATTERSON_DOCETAXEL_RESISTANCE | 0.000187 | 0.031433 |
| MORF_PPP5C | 0.000191 | 0.031433 |
| DNA_REPAIR | 0.000198 | 0.031826 |
| V$NFY_Q6_01 | 0.000206 | 0.032314 |
| XU_HGF_TARGETS_INDUCED_BY_AKT1_48H R_UP |
0.000218 | 0.033408 |
| WATANABE_RECTAL_CANCER_RADIOTHER APY_RESPONSIVE_DN |
0.000245 | 0.035718 |
| MORF_CCNF | 0.000241 | 0.035718 |
| REGULATION_OF_LIPID_METABOLIC_PROCE SS |
0.000249 | 0.035718 |
| WHITE_NEUROBLASTOMA_WITH_1P36.3_DEL ETION |
0.000258 | 0.036278 |
| REGULATION_OF_SMALL_GTPASE_MEDIATE D_SIGNAL_TRANSDUCTION |
0.000338 | 0.043476 |
| LAMELLIPODIUM | 0.000344 | 0.043476 |
| REACTOME_GLUTAMATE_NEUROTRANSMIT TER_RELEASE_CYCLE |
0.000331 | 0.043476 |
| TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSI ON_SUSTAINED_IN_GRANULOCYTE_UP |
0.000325 | 0.043476 |
| V$IRF_Q6 | 0.000318 | 0.043476 |
| V$CRX_Q4 | 0.000348 | 0.043476 |
| PENG_LEUCINE_DEPRIVATION_UP | 0.000363 | 0.044551 |
| chr6q24 | 0.000386 | 0.046488 |
| INDUCTION_OF_APOPTOSIS_BY_INTRACELL ULAR_SIGNALS |
0.000409 | 0.048445 |
| module_471 | 0.000425 | 0.049432 |
| PUJANA_CHEK2_PCC_NETWORK | 0.000442 | 0.050452 |
| V$CREB_Q4_01 | 0.00047 | 0.050452 |
| PERINUCLEAR_REGION_OF_CYTOPLASM | 0.000486 | 0.050452 |
| GAZDA_DIAMOND_BLACKFAN_ANEMIA_ER YTHROID_DN |
0.000471 | 0.050452 |
| MATTIOLI_MULTIPLE_MYELOMA_WITH_14Q 32_TRANSLOCATIONS |
0.000482 | 0.050452 |
| PROTEIN_HOMODIMERIZATION_ACTIVITY | 0.000464 | 0.050452 |
| GRAHAM_CML_DIVIDING_VS_NORMAL_DIVI DING_DN |
0.000465 | 0.050452 |
| LIU_TARGETS_OF_VMYB_VS_CMYB_UP | 0.000498 | 0.050942 |
| REACTOME_IONOTROPIC_ACTIVITY_OF_KAI NATE_RECEPTORS |
0.000527 | 0.053129 |
| PYEON_CANCER_HEAD_AND_NECK_VS_CER VICAL_DN |
0.000553 | 0.054085 |
| ZHANG_PROLIFERATING_VS_QUIESCENT | 0.000548 | 0.054085 |
| EXTERNAL_SIDE_OF_PLASMA_MEMBRANE | 0.000604 | 0.058227 |
| GNF2_APEX1 | 0.00062 | 0.058953 |
| ZUCCHI_METASTASIS_DN | 0.000638 | 0.059768 |
| SNIJDERS_AMPLIFIED_IN_HEAD_AND_NECK_ TUMORS |
0.000651 | 0.060177 |
| V$USF_C | 0.000708 | 0.062681 |
| RNTCANNRNNYNATTW_UNKNOWN | 0.000689 | 0.062681 |
| DEPHOSPHORYLATION | 0.000715 | 0.062681 |
| chr5q34 | 0.000713 | 0.062681 |
| RHEIN_ALL_GLUCOCORTICOID_THERAPY_D N |
0.000727 | 0.062882 |
| CELLULAR_CARBOHYDRATE_CATABOLIC_P ROCESS |
0.000743 | 0.063492 |
| REGULATION_OF_RAS_PROTEIN_SIGNAL_TR ANSDUCTION |
0.000757 | 0.06388 |
| RICKMAN_HEAD_AND_NECK_CANCER_D | 0.000767 | 0.06388 |
| module_441 | 0.00079 | 0.064239 |
| REGULATION_OF_RAS_GTPASE_ACTIVITY | 0.000815 | 0.064239 |
| CHIBA_RESPONSE_TO_TSA_UP | 0.000816 | 0.064239 |
| SEIDEN_ONCOGENESIS_BY_MET | 0.000811 | 0.064239 |
| MORI_MATURE_B_LYMPHOCYTE_DN | 0.000818 | 0.064239 |
| ION_TRANSMEMBRANE_TRANSPORTER_ACT IVITY |
0.000836 | 0.064863 |
| TIEN_INTESTINE_PROBIOTICS_24HR_UP | 0.000879 | 0.067459 |
| SENGUPTA_NASOPHARYNGEAL_CARCINOM A_WITH_LMP1_UP |
0.000902 | 0.068386 |
| REGULATION_OF_CATABOLIC_PROCESS | 0.000926 | 0.069418 |
| TSAI_DNAJB4_TARGETS_DN | 0.000946 | 0.069432 |
| DNA_DAMAGE_RESPONSESIGNAL_TRANSDU CTION_RESULTING_IN_INDUCTION_OF_APOP TOSIS |
0.000939 | 0.069432 |
| KEGG_DRUG_METABOLISM_OTHER_ENZYM ES |
0.00099 | 0.070374 |
| ENK_UV_RESPONSE_EPIDERMIS_UP | 0.000973 | 0.070374 |
| NUCLEOBASENUCLEOSIDENUCLEOTIDE_AND_N UCLEIC_ACID_TRANSMEMBRANE_TRAN SPORTER_ACTIVITY |
0.000986 | 0.070374 |
| KEGG_LIMONENE_AND_PINENE_DEGRADATI ON |
0.001016 | 0.07146 |
| SAGIV_CD24_TARGETS_UP | 0.001083 | 0.075354 |
| NUCLEOBASENUCLEOSIDENUCLEOTIDE_AN D_NUCLEIC_ACID_TRANSPORT |
0.001155 | 0.076817 |
| JISON_SICKLE_CELL_DISEASE_UP | 0.001119 | 0.076817 |
| module_528 | 0.001156 | 0.076817 |
| ONDER_CDH1_TARGETS_1_UP | 0.001145 | 0.076817 |
| TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSI ON_16D_UP |
0.001161 | 0.076817 |
| SARRIO_EPITHELIAL_MESENCHYMAL_TRAN SITION_UP |
0.001194 | 0.078262 |
| chr6p | 0.001286 | 0.083098 |
| ZIRN_TRETINOIN_RESPONSE_DN | 0.001293 | 0.083098 |
| PACHER_TARGETS_OF_IGF1_AND_IGF2_UP | 0.001389 | 0.087629 |
| PAPASPYRIDONOS_UNSTABLE_ATEROSCLER OTIC_PLAQUE_DN |
0.001384 | 0.087629 |
| REACTOME_GLYCOGEN_BREAKDOWN_GLY COGENOLYSIS |
0.001428 | 0.089249 |
| GGTAACC,MIR-409-5P | 0.001467 | 0.090596 |
| EXTRACELLULAR_SPACE | 0.001476 | 0.090596 |
| ZHAN_MULTIPLE_MYELOMA_CD2_DN | 0.001539 | 0.093601 |
| REGULATION_OF_GTPASE_ACTIVITY | 0.00161 | 0.096446 |
| REACTOME_ACTIVATION_OF_CHAPERONES_ BY_IRE1_ALPHA |
0.001615 | 0.096446 |
| TGAGATT,MIR-216 | 0.001668 | 0.096635 |
| OKUMURA_INFLAMMATORY_RESPONSE_LPS | 0.001654 | 0.096635 |
| V$IRF1_Q6 | 0.001668 | 0.096635 |
| MOOTHA_HUMAN_MITODB_6_2002 | 0.001675 | 0.096635 |
| TGAYRTCA_V$ATF3_Q6 | 0.001731 | 0.098992 |
| LOPES_METHYLATED_IN_COLON_CANCER_ UP |
0.0018 | 0.099652 |
| BASSO_HAIRY_CELL_LEUKEMIA_DN | 0.001801 | 0.099652 |
| HONRADO_BREAST_CANCER_BRCA1_VS_BR CA2 |
0.001772 | 0.099652 |
| MORF_PSMF1 | 0.001769 | 0.099652 |