Table 5.
Biological pathways associated with severe BPD in survivors, as compared to survivors without BPD. Pathways from the annotated gene sets of the molecular signatures database at the Broad Institute (http://www.broadinstitute.org/gsea/msigdb/index.jsp) are listed in order of increasing false discovery rate (FDR). Only pathways with FDR <0.1 are shown.
| Pathway Names | P values | FDR |
|---|---|---|
| PHOSPHORUS_OXYGEN_LYASE_ACTIVITY | 3.91E-08 | 0.000132037 |
| CYCLASE_ACTIVITY | 2.55E-08 | 0.000132037 |
| KUMAMOTO_RESPONSE_TO_NUTLIN_3A_UP | 1.22E-06 | 0.002374878 |
| GNF2_PRDX2 | 1.41E-06 | 0.002374878 |
| SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6 | 2.69E-06 | 0.003636936 |
| MORF_RAP1A | 4.01E-06 | 0.004511149 |
| GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESC ENT_UP |
5.99E-06 | 0.005773791 |
| TOMLINS_PROSTATE_CANCER_UP | 6.89E-06 | 0.005811578 |
| VALK_AML_CLUSTER_2 | 9.42E-06 | 0.006927232 |
| GLUCOSE_CATABOLIC_PROCESS | 1.03E-05 | 0.006927232 |
| MAP_KINASE_ACTIVITY | 1.57E-05 | 0.008805869 |
| MITOCHONDRION | 1.49E-05 | 0.008805869 |
| V$CREB_02 | 2.13E-05 | 0.011048338 |
| REACTOME_TRANSMISSION_ACROSS_CHEMICAL _SYNAPSES |
2.51E-05 | 0.012111145 |
| MORF_BRCA1 | 5.17E-05 | 0.018918766 |
| ATAAGCT,MIR-21 | 6.17E-05 | 0.018918766 |
| RODRIGUES_NTN1_AND_DCC_TARGETS | 5.41E-05 | 0.018918766 |
| TCCCCAC,MIR-491 | 5.87E-05 | 0.018918766 |
| REACTOME_NOREPINEPHRINE_NEUROTRANSMI TTER_RELEASE_CYCLE |
5.27E-05 | 0.018918766 |
| NAKAMURA_CANCER_MICROENVIRONMENT_DN | 6.01E-05 | 0.018918766 |
| KCCGNSWTTT_UNKNOWN | 5.54E-05 | 0.018918766 |
| BIOCARTA_CCR5_PATHWAY | 5.95E-05 | 0.018918766 |
| RESPONSE_TO_ENDOGENOUS_STIMULUS | 7.72E-05 | 0.020857418 |
| TRANSCRIPTION_COACTIVATOR_ACTIVITY | 7.32E-05 | 0.020857418 |
| XU_HGF_TARGETS_INDUCED_BY_AKT1_48HR_U P |
7.59E-05 | 0.020857418 |
| DELAYED_RECTIFIER_POTASSIUM_CHANNEL_A CTIVITY |
8.90E-05 | 0.022241771 |
| RESPONSE_TO_DNA_DAMAGE_STIMULUS | 8.76E-05 | 0.022241771 |
| FERRARI_RESPONSE_TO_FENRETINIDE_DN | 9.70E-05 | 0.02337315 |
| module_428 | 0.000103 | 0.023984694 |
| MORF_ATRX | 0.000113 | 0.025358723 |
| GCM_GSPT1 | 0.000122 | 0.026655373 |
| WINTER_HYPOXIA_UP | 0.000139 | 0.029219502 |
| TRANSCRIPTION_ACTIVATOR_ACTIVITY | 0.00015 | 0.030772585 |
| NELSON_RESPONSE_TO_ANDROGEN_UP | 0.000176 | 0.034427242 |
| WATANABE_RECTAL_CANCER_RADIOTHERAPY_ RESPONSIVE_DN |
0.000179 | 0.034427242 |
| TAGCTTT,MIR-9 | 0.000189 | 0.034900695 |
| EXTERNAL_SIDE_OF_PLASMA_MEMBRANE | 0.000196 | 0.034900695 |
| MCCLUNG_DELTA_FOSB_TARGETS_2WK | 0.000192 | 0.034900695 |
| REGULATION_OF_SMALL_GTPASE_MEDIATED_SI GNALTRANSDUCTION |
0.000216 | 0.036492426 |
| PUJANA_CHEK2_PCC_NETWORK | 0.000216 | 0.036492426 |
| WHITE_NEUROBLASTOMA_WITH_1P36.3_DELETI ON |
0.000228 | 0.037550752 |
| CYTOSOLIC_PART | 0.000242 | 0.038012621 |
| chr6q24 | 0.000241 | 0.038012621 |
| BENPORATH_ES_CORE_NINE_CORRELATED | 0.000249 | 0.038221556 |
| SENGUPTA_NASOPHARYNGEAL_CARCINOMA_W ITH_LMP1_UP |
0.000265 | 0.039765851 |
| SAGIV_CD24_TARGETS_UP | 0.000315 | 0.04177443 |
| KEGG_DRUG_METABOLISM_OTHER_ENZYMES | 0.00031 | 0.04177443 |
| RHEIN_ALL_GLUCOCORTICOID_THERAPY_DN | 0.000309 | 0.04177443 |
| REACTOME_CLASS_C3_METABOTROPIC_GLUTA MATE_PHEROMONE_RECEPTORS |
0.000306 | 0.04177443 |
| chr3p25 | 0.000316 | 0.04177443 |
| V$CREB_Q4_01 | 0.000306 | 0.04177443 |
| LAMELLIPODIUM | 0.000338 | 0.043890934 |
| ZUCCHI_METASTASIS_DN | 0.000372 | 0.047406175 |
| MOREAUX_MULTIPLE_MYELOMA_BY_TACI_UP | 0.000383 | 0.047933234 |
| REACTOME_STEROID_HORMONE_BIOSYNTHESIS | 0.000393 | 0.048235755 |
| chr3p14 | 0.00041 | 0.048235755 |
| LEE_INTRATHYMIC_T_PROGENITOR | 0.000404 | 0.048235755 |
| SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITI ON_UP |
0.000414 | 0.048235755 |
| module_441 | 0.000431 | 0.049268618 |
| GNF2_APEX1 | 0.00044 | 0.049520971 |
| PERINUCLEAR_REGION_OF_CYTOPLASM | 0.000448 | 0.049520971 |
| V$USF_C | 0.000482 | 0.052423429 |
| MORF_CCNF | 0.000495 | 0.053037318 |
| V$NFY_Q6_01 | 0.000536 | 0.056482951 |
| REGULATION_OF_RAS_PROTEIN_SIGNAL_TRANS DUCTION |
0.000597 | 0.057783747 |
| LINDGREN_BLADDER_CANCER_CLUSTER_2B | 0.000599 | 0.057783747 |
| LOPES_METHYLATED_IN_COLON_CANCER_UP | 0.000594 | 0.057783747 |
| BASSO_HAIRY_CELL_LEUKEMIA_DN | 0.00057 | 0.057783747 |
| GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTH ROID_DN |
0.000561 | 0.057783747 |
| REACTOME_GLUTAMATE_NEUROTRANSMITTER _RELEASE_CYCLE |
0.000584 | 0.057783747 |
| TSAI_DNAJB4_TARGETS_DN | 0.000646 | 0.058786732 |
| PYEON_CANCER_HEAD_AND_NECK_VS_CERVIC AL_DN |
0.000669 | 0.058786732 |
| TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_ SUSTAINED_IN_GRANULOCYTE_UP |
0.000661 | 0.058786732 |
| GGTAACC,MIR-409-5P | 0.000671 | 0.058786732 |
| REGULATION_OF_CATABOLIC_PROCESS | 0.000647 | 0.058786732 |
| NUCLEOBASENUCLEOSIDENUCLEOTIDE_AND_N UCLEIC_ACID_TRANSPORT |
0.000645 | 0.058786732 |
| CELLULAR_CARBOHYDRATE_CATABOLIC_PROC ESS |
0.000663 | 0.058786732 |
| MCBRYAN_PUBERTAL_BREAST_5_6WK_UP | 0.000698 | 0.059610192 |
| RICKMAN_HEAD_AND_NECK_CANCER_D | 0.000696 | 0.059610192 |
| PATTERSON_DOCETAXEL_RESISTANCE | 0.000719 | 0.060660099 |
| DNA_REPAIR | 0.000744 | 0.061980193 |
| REGULATION_OF_RAS_GTPASE_ACTIVITY | 0.000769 | 0.063320275 |
| SNIJDERS_AMPLIFIED_IN_HEAD_AND_NECK_TU MORS |
0.000804 | 0.065381496 |
| MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_25 | 0.000831 | 0.066760855 |
| REGULATION_OF_GTPASE_ACTIVITY | 0.000917 | 0.071987568 |
| CHIARETTI_T_ALL_REFRACTORY_TO_THERAPY | 0.000917 | 0.071987568 |
| module_471 | 0.000932 | 0.072274597 |
| MAYBURD_RESPONSE_TO_L663536_UP | 0.001005 | 0.074582373 |
| V$IRF_Q6 | 0.000987 | 0.074582373 |
| TGAGATT,MIR-216 | 0.000994 | 0.074582373 |
| MATTIOLI_MULTIPLE_MYELOMA_WITH_14Q 32_TRANSLOCATIONS |
0.001002 | 0.074582373 |
| REACTOME_IONOTROPIC_ACTIVITY_OF_KAINAT E_RECEPTORS |
0.001081 | 0.077418566 |
| REACTOME_GLYCOGEN_BREAKDOWN_GLYCOG ENOLYSIS |
0.00109 | 0.077418566 |
| CCCNNGGGAR_V$OLF1_01 | 0.001076 | 0.077418566 |
| RNTCANNRNNYNATTW_UNKNOWN | 0.001062 | 0.077418566 |
| HENDRICKS_SMARCA4_TARGETS_UP | 0.001129 | 0.079382915 |
| MORF_PPP5C | 0.001202 | 0.081971096 |
| CHIBA_RESPONSE_TO_TSA_UP | 0.001195 | 0.081971096 |
| GTGTGAG,MIR-342 | 0.001186 | 0.081971096 |
| PUJANA_BRCA1_PCC_NETWORK | 0.001284 | 0.086662282 |
| PENG_LEUCINE_DEPRIVATION_UP | 0.00132 | 0.087158417 |
| ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TN F_UP |
0.001309 | 0.087158417 |
| VICENT_METASTASIS_UP | 0.00133 | 0.087158417 |
| GNF2_ANP32B | 0.001384 | 0.088728588 |
| DEPHOSPHORYLATION | 0.001389 | 0.088728588 |
| V$IRF2_01 | 0.001393 | 0.088728588 |
| HASINA_NOL7_TARGETS_DN | 0.001413 | 0.089142284 |
| INDUCTION_OF_APOPTOSIS_BY_INTRACELLULA R_SIGNALS |
0.001441 | 0.090064396 |
| OKUMURA_INFLAMMATORY_RESPONSE_LPS | 0.001493 | 0.092456662 |
| NUCLEAR_UBIQUITIN_LIGASE_COMPLEX | 0.001523 | 0.093434244 |
| TGAYRTCA_V$ATF3_Q6 | 0.001538 | 0.093522358 |
| FERREIRA_EWINGS_SARCOMA_UNSTABLE_VS_S TABLE_UP |
0.001631 | 0.09598751 |
| REGULATION_OF_LIPID_METABOLIC_PROCESS | 0.001594 | 0.09598751 |
| V$PAX3_01 | 0.001635 | 0.09598751 |
| BLUM_RESPONSE_TO_SALIRASIB_UP | 0.00165 | 0.09598751 |
| chr6p | 0.001628 | 0.09598751 |
| ENK_UV_RESPONSE_EPIDERMIS_UP | 0.001673 | 0.096498142 |
| BIOCARTA_LONGEVITY_PATHWAY | 0.001722 | 0.097653706 |
| chr5q34 | 0.001707 | 0.097653706 |
| NUCLEOLUS | 0.00174 | 0.097890086 |
| PACHER_TARGETS_OF_IGF1_AND_IGF2_UP | 0.001832 | 0.098235946 |
| AXON | 0.001769 | 0.098235946 |
| TIEN_INTESTINE_PROBIOTICS_24HR_UP | 0.001796 | 0.098235946 |
| JISON_SICKLE_CELL_DISEASE_UP | 0.00181 | 0.098235946 |
| CTGCAGY_UNKNOWN | 0.001848 | 0.098235946 |
| REACTOME_ACTIVATION_OF_CHAPERONES_BY_ IRE1_ALPHA |
0.001839 | 0.098235946 |
| KEGG_LIMONENE_AND_PINENE_DEGRADATION | 0.001808 | 0.098235946 |
| REACTOME_DOWN_STREAM_SIGNAL_TRANSDU CTION |
0.002053 | 0.099165696 |
| NUCLEOBASENUCLEOSIDENUCLEOTIDE_AND_N UCLEIC_ACID_TRANSMEMBRANE_TRANSPORTE R_ACTIVITY |
0.001938 | 0.099165696 |
| REACTOME_PYRUVATE_METABOLISM | 0.001953 | 0.099165696 |
| FUNG_IL2_SIGNALING_1 | 0.002071 | 0.099165696 |
| PAPASPYRIDONOS_UNSTABLE_ATEROSCLEROTI C_PLAQUE_DN |
0.002003 | 0.099165696 |
| ZHANG_PROLIFERATING_VS_QUIESCENT | 0.001967 | 0.099165696 |
| CAAGGAT,MIR-362 | 0.001995 | 0.099165696 |
| PENG_RAPAMYCIN_RESPONSE_UP | 0.002047 | 0.099165696 |
| V$CRX_Q4 | 0.002058 | 0.099165696 |
| EXTRACELLULAR_SPACE | 0.001993 | 0.099165696 |
| CARBOHYDRATE_CATABOLIC_PROCESS | 0.001922 | 0.099165696 |
| TTCCGTT,MIR-191 | 0.002022 | 0.099165696 |
| HONRADO_BREAST_CANCER_BRCA1_VS_BRCA2 | 0.001971 | 0.099165696 |
| SEIDEN_ONCOGENESIS_BY_MET | 0.001986 | 0.099165696 |
| module_318 | 0.002096 | 0.099652829 |