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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: J Pediatr. 2014 Nov 6;166(3):531–537.e13. doi: 10.1016/j.jpeds.2014.09.052

Table 6.

Biological pathways associated with BPD or death classified by race, as compared to survivors without BPD. Pathways from the annotated gene sets of the molecular signatures database at the Broad Institute (http://www.broadinstitute.org/gsea/msigdb/index.jsp) are listed in order of increasing false discovery rate (FDR). Only the top 12 pathways are shown for All infants, White infants, and Black infants.

All infants White infants Black infants
Pathway P
value
FDR Pathway P
value
FDR Pathway P value FDR
GACAATC,
MIR-219
1.41E-
08
9.52E
-05
module_
320
1.82E
-49
1.23
E-45
RODRIGU
ES_THYR
OID_CAR
CINOMA_
DN
7.80E-
07
0.005262
NUCLEAR_
UBIQUITIN
_LIGASE_C
OMPLEX
2.16E-
07
0.000
73
GNF2_B
UB1
2.29E
-41
7.73
E-38
TOMLINS
_METAST
ASIS_DN
4.91E-
06
0.007876
YRCCAKN
NGNCGC_U
NKNOWN
7.11E-
07
0.001
6
GNF2_T
TK
1.03E
-31
2.32
E-28
ATAAGCT
,MIR-21
5.14E-
06
0.007876
V$E2F_Q2 9.88E-
07
0.001
668
GNF2_S
MC2L1
1.38E
-31
2.33
E-28
KEGG_CE
LL_ADHE
SION_MO
LECULES
_CAMS
2.39E-
06
0.007876
NEURON_P
ROJECTION
1.37E-
05
0.015
893
GNF2_H
MMR
4.80E
-24
6.48
E-21
module_34
9
5.83E-
06
0.007876
V$GABP_B 1.41E-
05
0.015
893
GNF2_E
SPL1
8.12E
-23
9.14
E-20
BEGUM_T
ARGETS_
OF_PAX3_
FOXO1_F
USION_UP
8.48E-
06
0.008177
TOMLINS_
METASTAS
ISDN
1.66E-
05
0.015
965
GNF2_C
ENPE
1.23E
-22
CHEOK_R
ESPONSE_
TO_MERC
APTOPUR
INE_AND_
HD_MTX_
UP
8.15E-
06
0.008177
NUCLEOBA
SENUCLEO
SIDENUCL
EOTIDE_KI
NASE_ACTI
VITY
2.74E-
05
0.018
801
GNF2_C
DC20
5.47E
-22

AMIT_EG
F_RESPO
NSE_480_
HELA
1.00E-
05
0.008437
V$E2F_Q4 3.27E-
05
0.018
801
module_
244
1.14E
-21
8.55
E-19
CELLULA
R_MACRO
MOLECUL
E_METAB
OLIC_PRO
CESS
1.98E-
05
0.014845
RUIZ_TNC_
TARGETS_
DN
2.99E-
05
0.018
801
GNF2_C KS1B 3.48E
-20
2.35
E-17
KENNY_C
TNNB1_T
ARGETS_
DN
2.26E-
05
0.015232
JAEGER_M
ETASTASIS
_UP
3.34E-
05
0.018
801
MORI_L
ARGE_P
RE_BII_
LYMPH
OCYTE_
UP
2.86E
-19
1.76
E-16
PROTEIN_
UBIQUITI
NATION
2.94E-
05
0.017542
SUGAR_BI
NDING
2.71E-
05
0.018
801
GNF2_C
KS2
7.66E
-19
4.31
E-16
CELLULA
R_PROTEI
N_METAB
OLIC_PRO
CESS
3.27E-
05
0.017542