Table 7.
Six of the nine genes (represented by 20 probesets) identified as having the top 10 SNPs are on HG-U133 plus array for gene expression. Two genes (NUAK1 and GRIP1) show significantly reduced expression in BPD lung tissue at p<0.05 and CD44 shows a trend towards increased expression in BPD, but none of the identified SNPs were found to have a more than two-fold change in expression level.
| Gene Symbol | Gene Description | Entrez Gene Id |
HU- 133plus2 ProbesetID |
Adj P- value |
Fold Change |
Log Fold Change |
|---|---|---|---|---|---|---|
| NUAK1 | “NUAK family, SNF1-like kinase, 1” |
9891 | 204589_at | 0.0061 | 0.60197 1 |
− 0.73224 |
| GRIP1 | glutamate receptor interacting protein 1 |
23426 | 235957_at | 0.0227 | 0.82473 | − 0.27801 |
| CD44 | CD44 molecule (Indian blood group) |
960 | 204489_s_at | 0.0638 | 1.22524 1 |
0.29306 6 |
| CD44 | CD44 molecule (Indian blood group) |
960 | 210916_s_at | 0.1006 | 1.34114 9 |
0.42346 9 |
| CD44 | CD44 molecule (Indian blood group) |
960 | 209835_x_at | 0.1152 | 1.25162 9 |
0.32380 7 |
| CD44 | CD44 molecule (Indian blood group) |
960 | 204490_s_at | 0.1160 | 1.25926 2 |
0.33257 9 |
| CD44 | CD44 molecule (Indian blood group) |
960 | 212014_x_at | 0.1312 | 1.23871 3 |
0.30884 3 |
| CD44 | CD44 molecule | 960 | 1557905_s_a | 0.1570 | 1.29494 | 0.37288 |
| (Indian blood group) | t | 5 | ||||
| CD44 | CD44 molecule (Indian blood group) |
960 | 212063_at | 0.2456 | 1.08290 7 |
0.11491 |
| GALNTL6 | UDP-N-acetyl- alpha-D- galactosamine:polyp eptide N- acetylgalactosaminyl transferase-like 6 |
442117 | 1555273_at | 0.3811 | 1.04195 8 |
0.05929 8 |
| KCNH7 | “potassium voltage- gated channel, subfamily H (eagrelated), member 7” |
90134 | 224099_at | 0.4570 | 1.05710 3 |
0.08011 7 |
| ADARB2 | “adenosine deaminase, RNA- specific, B2” |
105 | 237437_s_at | 0.5247 | 1.02396 5 |
0.03416 6 |
| CD44 | CD44 molecule (Indian blood group) |
960 | 229221_at | 0.5401 | 1.11443 1 |
0.15630 7 |
| CD44 | CD44 molecule (Indian blood group) |
960 | 1565868_at | 0.6141 | 0.92827 6 |
− 0.10737 |
| CD44 | CD44 molecule (Indian blood group) |
960 | 217523_at | 0.6336 | 1.05519 6 |
0.07751 1 |
| ADARB2 | “adenosine | 105 | 220648_at | 0.6381 | 1.04929 | 0.06941 |
| deaminase, RNA- specific, B2” |
4 | |||||
| GRIP1 | glutamate receptor interacting protein 1 |
23426 | 214018_at | 0.6900 | 1.01674 9 |
0.02396 3 |
| CD44 | CD44 molecule (Indian blood group) |
960 | 234418_x_at | 0.7458 | 1.05579 9 |
0.07833 5 |
| KCNH7 | “potassium voltage- gated channel, subfamily H (eag- related), member 7” |
90134 | 1555316_a_a t |
0.7512 | 1.01244 6 |
0.01784 5 |
| CD44 | CD44 molecule (Indian blood group) |
960 | 234411_x_at | 0.8856 | 1.01904 | 0.02721 |