Figure 1.
Type 5 adenovirus can be detected in the Eustachian tubes and middle ear bullae of chinchillas following intranasal inoculation. Chinchillas were inoculated with type 5 adenovirus at an inoculum of 6 × 108, 3 × 107, or 3 × 106 infectious units. At 7 and 10 days postinoculation, animals were euthanized and adenovirus was quantitated in the nasopharynx (a), Eustachian tubes (b), and middle ear (c). The solid lines indicate geometric mean viral infectious units. The dashed line indicates the limit of detection. Each data point in (b) and (c) represents a single Eustachian tube or single middle ear bulla, respectively.