Table 3.

Gene expression, expressed as fold of expression in healthy controls, from bone cores and primary human osteoblasts from 24 dialysis patients undergoing bone biopsy. Data are expressed as medians (IQ ranges). A significant (p<0.05) difference in gene expression in CKD samples relative to healthy controls is denoted by an asterisk. Bold font denotes significant correlations between cores and cells.

	Core	Cells	Correlation between gene expression in cores and cells
Osteoblast markers
OSX	8.84 (4.74, 13.84) *	2.93 (1.01, 5.20) *	r=0.30, p=0.18
Runx2	3.36 (2.53, 5.49) *	2.61 (1.79, 3.40) *	r=0.30, p=0.18
Col1A1	3.83 (3.28, 4.37) *	1.37 (1.10, 1.70) *	r=0.34, p=0.12
BGLAP	7.91 (3.92, 10.44) *	1.13 (0.56, 2.03)	r=0.19, p=0.39
OPG	4.23 (3.11, 7.08) *	1.38 (0.64, 1.92) *	r=0.44, p=0.04
ALPL	5.15 (3.21, 6.41) *	2.96 (1.79, 5.59) *	r=0.03, p=0.90
MGP	3.23 (1.69, 4.07) *	2.35 (1.24, 3.65) *	r=0.18, p=0.43
BMP2	2.93 (1.81, 5.14) *	2.46 (1.74, 4.22) *	r= − 0.06, p=0.80
Cell signaling
Cyp24A1	0.04 (0.01, 0.43) *	1.28 (0.45, 3.69)	r=0.42, p=0.05
Cyp27B1	2.45 (1.66, 4.13) *	0.96 (0.77, 1.75)	r=0.73, p=0.0001
VDR	2.49 (2.07, 3.88) *	2.79 (1.98, 3.97) *	r=0.45, p=0.04
FGFR1	4.33 (2.52, 6.05) *	1.68 (1.13, 2.09) *	r=0.49, p=0.02
PHEX	6.46 (4.42, 12.48) *	0.99 (0.70, 1.60)	r=0.36, p=0.10
RANKL	6.50 (4.46, 12.08) *	1.63 (0.24, 2.98) *	r= − 0.07, p=0.75
NHERF1	1.04 (0.82, 1.65)	2.42 (1.83, 3.19) *	r=0.64, p=0.001
PTHR1	8.25 (4.91, 11.08) *	4.77 (1.83, 6.73) *	r= − 0.18, p=0.43
IGF1	1.60 (1.19, 2.51) *	4.14 (1.96, 9.15) *	r=0.47, p=0.03
Osteocyte markers
DMP 1	10.06 (5.21, 16.32) *	0.96 (0.53, 1.04)	r=0.17, p=0.46
FGF23	3.88 (1.55, 8.95) *	1.10 (0.89, 1.22)	r= − 0.06, p=0.80
MEPE	6.29 (4.38, 11.62) *	3.82 (2.22, 9.86) *	r=0.04, p=0.85
SOST	4.15 (2.77, 9.02) *	Not detected	NA