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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Hepatol Res. 2014 Oct 7;45(7):794–803. doi: 10.1111/hepr.12411

Figure 3. Inhibition of the CXCR4/CXCL12 chemokine axis with continuous infusion of AMD3100 in the chronic CCl4 model of liver fibrosis promotes liver inflammation.

Figure 3

FACS analysis of circulating leukocytes showed that AMD3100 increased circulating inflammatory cells in both oil and CCl4 treated mice (A), with a specific increase in neutrophil populations (B). Additionally, isolated liver infiltrating inflammatory cells showed an increase in the total number of CD45-positive cells/gram of liver tissue (C) with a similar increase in the absolute number of neutrophils (D) in mice receiving AMD3100 both in oil and CCl4 treated mice. n=6-12, *P<0.05, **P<.01, ***P<.001.