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. Author manuscript; available in PMC: 2016 Apr 2.
Published in final edited form as: Toxicol Lett. 2015 Feb 10;234(1):40–49. doi: 10.1016/j.toxlet.2015.02.004

Fig. 6. Immunohistochemistry staining for CHOP protein in the livers of mice treated with Nano-ZnO.

Fig. 6

Mice were orally administrated physiological saline (A, control), 200 mg/kg (B), or 400 mg/kg (C) of Nano-ZnO for 90 consecutive days. (A–C) Liver sections were stained immunohistochemically for the ER-associated apoptosis-related protein CHOP. The brown granules in the nucleus and cytoplasm indicate the presence of CHOP. Scale bars in A–C indicate 50 µm. (D) Semi-quantitative analysis of immunohistochemical staining of CHOP in the livers as described in the Materials and Methods. Values are expressed as mean ± SD (n=6–8). * p<0.05 vs. control.