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. Author manuscript; available in PMC: 2016 Feb 26.
Published in final edited form as: Cell. 2015 Feb 26;160(5):904–912. doi: 10.1016/j.cell.2015.01.041

Figure 2. MR78 binds both MARV and EBOV GPcl at the apex of GP1.

Figure 2

(A) 3.6 Å crystal structure of MARV GPcl in complex with Fab MR78. Each GP1 is colored a different shade of purple, GP2 is gray, and the MR78 Fab is in yellow. (B) 8 Å structure of EBOV GPcl in complex with Fab MR78, determined by molecular replacement and rigid body refinement. Each EBOV GP1 is colored a different shade of blue and GP2 is gray. See also Figure S2. Fab MR78 (yellow) binds the apex of GP1 of both viruses.

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