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. Author manuscript; available in PMC: 2016 Feb 26.
Published in final edited form as: Cell. 2015 Feb 26;160(5):904–912. doi: 10.1016/j.cell.2015.01.041

Figure 4. Similarity in recognition of the putative receptor-binding site by MR78 and the Ebola virus glycan cap.

Figure 4

(A) The CDR H3 of MR78 (yellow) reaches into the hydrophobic trough of GP1 (purple). F111.2 and Y112.2 of CDR H3 interact with P63, S67, W70, F72, I95 and I125 of MARV GP. (B) Similar residues of the EBOV glycan cap (white blue) bind into this trough on the surface of EBOV GP (blue), prior to enzymatic cleavage. Here, F225 and Y232 of the glycan cap interact with P80, T83, W86, F88, L111 and V141 in the trough (PDB ID; 3CSY).

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