Table 2.

Epistatic interactions that map to HiC interactions

Tissue	HiC interactions
	Epistatic	Non-epistatic	Odds ratio	P-value
Liver	14/34	913/9772	6.79	< 0.0001
Pre-Frontal Cortex	118/321	13450/125873	4.86	< 0.0001
Cerebellum	39/105	6758/77511	6.19	< 0.0001
Visual Cortex	19/66	3422/40882	4.43	< 0.0001

SNP pairs that map to HiC interactions (spatially proximate regions of the genome) are given as the proportion of epistatic interactions that map to at least one HiC interaction and the proportion of non-epistatic SNP pairs tested that map to at least one HiC interaction. The odds ratio that a pair of epistatic SNPs also maps to a HiC physical interaction is given for each tissue. Significance is assessed using a chi-squared test for goodness of fit.