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. 2015 Feb 25;15:82. doi: 10.1186/s12885-015-1065-8

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© Saito et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Growth stimulation by HGF and FGFs and growth inhibition by MET inhibitor and FGFR inhibitor. HGF stimulates the proliferation of two cell lines (KYSE170 and KYSE220) by more than 1.36 fold, while the addition of FGFs (1, 7, and 10) induces a 1.25-fold or higher growth stimulation in 11 cell lines. MET inhibitor (PHA-665752) inhibits proliferation by 25% or more in six cell lines. FGFR inhibitor (PD-173074) inhibits proliferation by 25% or more in six cell lines, three of which are also growth inhibited by MET inhibitor.