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The inhibitory effect of lapatinib on the proliferation of 22 cancer cell lines and the rescue effect of fibroblast culture supernatant against lapatinib-induced inhibition. Lapanitib (1 μM) inhibits cell proliferation by more than 50% in the majority of the ESCC cell lines. Addition of fibroblast supernatant rescues growth inhibition by lapatinib and recovers cell proliferation by 20% or more in 10 cell lines.
