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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Psychopharmacology (Berl). 2014 Mar 20;231(20):3941–3952. doi: 10.1007/s00213-014-3529-y

Table 2.

Drug effects on trial omissions and response latencies. Mean (± SEM) values are shown.

Ascending Delays Task Descending Delays Task


Drug, dose
(mg/kg)
Omissions Lever press latencies
(sec)
Omissions Lever press
latencies (sec)
Yohimbine
  Vehicle 4.6(1.2) 2.1(0.1) 8.6(1.6) 2.5 (0.1)
  0.6 3.2 (0.8) 1.9 (0.1) 4.2 (0.7) 1.9(0.1)***
  1.25 2.3 (0.8) 1.7(0.1)* 4.3 (0.7) 2.0(0.1)*
  2.5 1.7(0.7)* 1.9 (0.2) 6.1(1.3) 2.3 (0.2)
  5 4.5(1.0) 2.3(0.2) 12.9 (2.5) 3.0 (0.3)

Propranolol
  Vehicle 2.9 (0.8) 1.7(0.1) 10.8(1.6) 2.5 (0.2)
  1 2.7(0.7) 1.7(0.2) 12.0(2.2) 2.7 (0.2)
  3 2.7(0.5) 1.8(0.1) 9.6(1.9) 2.6 (0.3)
  10 5.0(1.3) 2.0(0.2) 15.2(3.5) 2.7 (0.3)

Prazosin
  Vehicle 4.1(1.2) 1.9 (0.2) 10.2(1.7) 2.4 (0.1)
  0.5 6.1(1.0) 2.1(0.1)
  1 7.6(2.1) 2.1(0.2)
  2 7.7(1.8) 2.3(0.1) 15.0(3.3) 3.1(0.3)*

Guanfacine
  Vehicle 4.1(0.9) 1.8(0.1) 11.1(2.9) 2.4 (0.2)
  0.06 6.0(1.6) 2.1(0.2)
  0.125 11.1(3.5) 2.7 (0.2)* 12.8(3.2) 2.8 (0.2)
  0.25 21.2(6.0)* 3.2(0.4)***

Asterisks indicate significance relative to vehicle:

*

p < 0.05,

***

p < 0.001