Table 2.
Ascending Delays Task | Descending Delays Task | |||
---|---|---|---|---|
Drug, dose (mg/kg) |
Omissions | Lever press latencies (sec) |
Omissions | Lever press latencies (sec) |
Yohimbine | ||||
Vehicle | 4.6(1.2) | 2.1(0.1) | 8.6(1.6) | 2.5 (0.1) |
0.6 | 3.2 (0.8) | 1.9 (0.1) | 4.2 (0.7) | 1.9(0.1)*** |
1.25 | 2.3 (0.8) | 1.7(0.1)* | 4.3 (0.7) | 2.0(0.1)* |
2.5 | 1.7(0.7)* | 1.9 (0.2) | 6.1(1.3) | 2.3 (0.2) |
5 | 4.5(1.0) | 2.3(0.2) | 12.9 (2.5) | 3.0 (0.3) |
Propranolol | ||||
Vehicle | 2.9 (0.8) | 1.7(0.1) | 10.8(1.6) | 2.5 (0.2) |
1 | 2.7(0.7) | 1.7(0.2) | 12.0(2.2) | 2.7 (0.2) |
3 | 2.7(0.5) | 1.8(0.1) | 9.6(1.9) | 2.6 (0.3) |
10 | 5.0(1.3) | 2.0(0.2) | 15.2(3.5) | 2.7 (0.3) |
Prazosin | ||||
Vehicle | 4.1(1.2) | 1.9 (0.2) | 10.2(1.7) | 2.4 (0.1) |
0.5 | 6.1(1.0) | 2.1(0.1) | ||
1 | 7.6(2.1) | 2.1(0.2) | ||
2 | 7.7(1.8) | 2.3(0.1) | 15.0(3.3) | 3.1(0.3)* |
Guanfacine | ||||
Vehicle | 4.1(0.9) | 1.8(0.1) | 11.1(2.9) | 2.4 (0.2) |
0.06 | 6.0(1.6) | 2.1(0.2) | ||
0.125 | 11.1(3.5) | 2.7 (0.2)* | 12.8(3.2) | 2.8 (0.2) |
0.25 | 21.2(6.0)* | 3.2(0.4)*** |
Asterisks indicate significance relative to vehicle:
p < 0.05,
p < 0.001