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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Oncogene. 2014 Sep 1;34(26):3429–3440. doi: 10.1038/onc.2014.273

Figure 8.

Figure 8

Effect of DFMO and MDL 72527 on PZ5056G-induced gastric pathology. Gerbils were infected with PZ5056G and treated with DFMO (D) or MDL 72527 (M) or the combination (D+M) as described in Figure 7. After 16 weeks gerbils were euthanized. (a) Gastritis score was assessed as in Figure 6. Each symbol represents a gerbil, with orange symbols indicating animals with dysplasia, and red symbols animals with carcinoma. All gerbils with no histologic gastritis were colonized when assessed by either culture or qPCR for the ureA gene. *P < 0.05 versus PZ5056G without treatment. (b) Frequency of advanced lesions. Left panel: dysplasia; right panel: carcinoma. (c) Representative H&E staining showing malignant appearing glands invading into the submucosa, top panels; and only gastritis in a gerbil treated with DFMO.