Table 6.
Regional volumes and effect sizes for group differences for all assessment points
| ROI | AP1 | AP1 Effect Size | AP2 | AP2 Effect Size | AP3 | AP3 Effect Size | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CON n=32 |
nsALC n=36 |
sALC n= 46 |
nsALC vs. CON |
sALC vs. CON |
sALC vs. nsALC |
CON n=32 |
nsALC n=44 |
sALC n= 67 |
nsALC vs. CON |
sALC vs. CON |
sALC vs. nsALC |
CON n=32 |
nsALC n=18 |
sALC n=18 |
nsALC vs. CON |
sALC vs. CON |
nsALC vs. sALC |
|
| Frontal GM | 221.1 (10.4) | 213.1 (10.4) | 212.8 (10.3) | 0.86* | 0.90$ | 0.03 | 222.4 (10.2) | 215.9 (10.3) | 214.4 (10.1) | 0.63* | 0.78$ | 0.09 | 222.0 (9.6) | 218.6 (9.3) | 218.0 (9.2) | 0.36 | 0.43 | 0.07 |
| Parietal GM | 123.2 (6.4) | 117.3 (6.5) | 117.2 (6.4) | 0.90* | 0.92$ | 0.01 | 123.1 (6.7) | 118.9 (6.7) | 118.1 (6.7) | 0.62* | 0.75$ | 0.12 | 123.8 (6.0) | 120.1 (6.1) | 119.9 (5.8) | 0.83* | 0.65$ | 0.17 |
| Temporal GM | 152.0 (6.1) | 147.1 (6.1) | 145.8 (6.0) | 0.70* | 1.02$ | 0.12 | 152.2 (7.0) | 147.3 (7.1) | 147.1 (6.9) | 0.69* | 0.72$ | 0.03 | 153.4 (7.0) | 147.2 (7.2) | 147.8 (6.9) | 0.87* | 0.80$ | 0.09 |
| Occipital GM | 56.3 (5.0) | 55.4 (5.0) | 53.4 (4.9) | 0.18 | 0.59$ | 0.40^ | 56.6 (4.8) | 55.9 (4.8) | 54.2 (4.7) | 0.15 | 0.52$ | 0.37 | 56.5 (4.8) | 56.4 (4.9) | 53.6 (4.7) | 0.02 | 0.63$ | 0.58^ |
| Total Cortical GM | 553.9 (19.6) | 533.6 (19.8) | 529.2 (19.9) | 1.03* | 1.25$ | 0.07 | 555.2 (20.0) | 538.6 (20.5) | 534.8 (19.8) | 0.82* | 1.02$ | 0.19 | 554.6 (17.9) | 542.1 (17.8) | 538.9 (17.9) | 0.70* | 0.88$ | 0.18 |
| Frontal WM | 206.9 (13.0) | 207.4 (13.1) | 207.3 (12.8) | 0.04 | 0.3 | 0.01 | 206.5 (13.1) | 208.5 (13.2) | 208.8 (13.1) | 0.22 | 0.23 | 0.01 | 206.8 (11.8) | 211.0 (12.2) | 210.4 (11.6) | 0.35 | 0.30 | 0.06 |
| Parietal WM | 94.5 (6.5) | 94.5 (6.4) | 95.0 (6.3) | 0.01 | 0.08 | 0.08 | 94.6 (6.8) | 94.8 (6.8) | 94.7 (6.7) | 0.02 | 0.01 | 0.01 | 95.0 (6.9) | 96.9 (7.1) | 97.2 (6.7) | 0.28 | 0.32 | 0.04 |
| Temporal WM | 57.6 (3.5) | 56.5 (3.5) | 56.8 (3.4) | 0.31 | 0.24 | 0.06 | 57.8 (3.8) | 56.7 (3.8) | 56.7 (3.7) | 0.29 | 0.29 | 0.00 | 58.0 (3.3) | 56.9 (3.4) | 57.5 (3.2) | 0.39 | 0.14 | 0.18 |
| Occipital WM | 35.6 (3.2) | 34.1 (3.2) | 34.0 (3.2) | 0.14 | 0.07 | 0.07 | 34.9 (3.5) | 34.6 (3.5) | 34.2 (3.4) | 0.21 | 0.09 | 0.12 | 34.8 (3.5) | 35.4 (3.6) | 35.0 (3.4) | 0.44 | 0.34 | 0.10 |
| Total Lobar WM | 394.8 (20.5) | 391.5 (20.6) | 390.8 (20.3) | 0.16 | 0.20 | 0.04 | 393.9 (21.6) | 392.7 (22.1) | 392.8 (21.5) | 0.05 | 0.03 | 0.01 | 395.8 (20.8) | 399.5 (21.4) | 400.3 (20.3) | 0.22 | 0.22 | 0.04 |
| Cerebellum | 123.3 (9.6) | 119.9 (9.7) | 119.3 (9.5) | 0.36 | 0.42 | 0.06 | 123.6 (9.1) | 121.8 (9.2) | 120.9 (9.0) | 0.19 | 0.29 | 0.10 | 124.1 (10.0) | 125.3 (10.4) | 120.7 (9.8) | 0.11 | 0.34 | 0.46 |
| Thalamus | 6.7 (1.1) | 5.7 (1.1) | 5.8 (1.0) | 0.99* | 0.93$ | 0.08 | 6.7 (1.1) | 5.8 (1.1) | 5.7 (1.1) | 0.80* | 0.88$ | 0.07 | 6.7 (1.1) | 6.3 (1.1) | 5.8 (1.0) | 0.44 | 0.91$ | 0.47 |
| Lenticular nucleus | 7.0 (1.0) | 6.5 (1.0) | 6.6 (1.0) | 0.59* | 0.50$ | 0.09 | 7.0 (1.0) | 6.4 (1.0) | 6.5 (1.0) | 0.57* | 0.50$ | 0.08 | 7.0 (0.9) | 6.4 (1.0) | 6.4 (1.0) | 0.57* | 0.57$ | 0.00 |
| Ventricular CSF | 25.7 (8.8) | 30.3 (9.0) | 27.5 (8.8) | 0.52 | 0.21 | 0.31 | 25.8 (9.1) | 28.3 (9.1) | 27.6 (9.0) | 0.27 | 0.20 | 0.08 | 26.2 (9.3) | 25.8 (9.8) | 28.4 (9.0) | 0.04 | 0.34 | 0.28 |
Note. Mean (standard deviation); reported values are estimated means from pairwise comparisons of CON, nsALC, and sALC;
*
nsALC mean volume < nsCON mean volume, p ≤ .017;
$
sALC mean volume < nsCON mean volume, p ≤ .017;
^
sALC mean volume < nsALC mean volume, p ≤ .017.
GM: gray matter. WM: white matter. CSF: cerebrospinal fluid