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Effects of niclosamide on tumor growth in ovarian cancer. (a) Mice were injected i.p. with SKOV3.ip1 cells and treated with niclosamide (0 and 200 mg/kg/day B.W.) by oral gavage for 5 weeks starting 3 days after i.p. injection. Tumor implant number and total tumor weight 5 weeks after niclosamide treatment are shown (n=6 each group). Cell proliferation and apoptosis were determined by immunoreactive Ki67 staining and TUNEL assay.
