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. 2014 Nov 28;56(2):132–142. doi: 10.3164/jcbn.14-76

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Copyright © 2015 JCBN

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Fig. 4 — Comparison of inflammatory mediators including iNOS and COX-2 according to extract solvent. (A) Isopropanol extracts reduces COX-2 protein expression. COX-2 protein expression was analyzed by Western blotting. Isopropanol extracts in the presence of LPS inhibited COX-2 protein in RGM1 cell in a dose-dependent manner. (B) Isopropanol extracts of Artemisia reduced more COX-2, iNOS, and IL-6 mRNA expression than ethanol extracts. COX-2, iNOS, and IL-6 mRNA expression were analyzed by RT-PCR. Isopropanol extracts in the presence of LPS inhibited COX-2, iNOS, and IL-6 mRNA expression in RGM1 cell in a dose-dependent manner. (C) Protein array for inflammatory mediators. CXCL-1, CXCL-16, and MCP-1 were inhibited in density in the isopropanol extracts treated group than ethanol extracts treated group. The low panel shows the relative intensity of decreased each cytokine.