Fig. 7.

Isopropranol extracts of Artemisia could rescue from stress related gastric damages, in which higher antioxidative, anti-inflammatory, and cytoprotective mechanisms were intervened. Rescuing action of Artemisia against stress-induced gastritis Improved biological actions of Artemisia with isopropanol extraction was validated in animal model. Isopropanol extracts of Artemisia offered three kinds of beneficial actions compared to ethanol extracts, higher antioxidative activities reflected with higher HO-1 and Nrf2 activation, higher anti-inflammatory actions accompanied with attenuated inflammatory cytokines, and higher chance of cytoprotection including HSP70 induction as well as decreased endothelin-1, all of these benefits from isopropanol extraction can orchestrate higher clinical efficacy of gastritis treatment.