Table 2.
Summary of TAVI patient population characteristics at baseline in current studies.
| Parameter | Orvin et al., 2014 [8] | Ghanem et al., 2013 [6] | Kahlert et al., 2012 [9] | Knipp et al., 2013 [10] | Rodés-Cabau et al., 2011 [11] | Kahlert et al., 2010 [12] | |
|---|---|---|---|---|---|---|---|
| n | 36 | 111 | 83 | 27 | 60 | 22 (ES) | 10 (MCV) |
|
| |||||||
| Demographics | |||||||
| Age, mean ± SD | 82.2 ± 4.2 | 80 ± 6 | 80.6 (79.3–81.8) | 82.2 ± 4.7 | 83 ± 7 | 78.3 (76.4–80.2) | 83.8 (79.2–88.4) |
| Male gender, % (n) | 52.8 (19) | 54 (60) | 57.8% (35) | 74.1 (20) | 50 (30) | 36 (14) | 60 (4) |
|
| |||||||
| Risk scores | |||||||
| Logistic EuroSCORE, mean ± SD | 14.9 ± 11.4 | 24.3 ± 14.7 | 20.7 (17.8–23.5) | 36.4 ± 13.2 | 18.9 ± 12.8 | 22.8 (16.5–29.2) | 17.9 (12.0–23.7) |
| Society of Thoracic Surgeons Score | 7.4 ± 4.1 | 8.5 ± 5.4 | 6.7 (5.7–7.7) | — | 7.7 ± 4.6 | — | — |
|
| |||||||
| Cognitive status | |||||||
| Mini-mental status exam, mean ± SD | 25.9 ± 3.3 | 25.4 ± 3.4 | 27.9 (27.5–28.3) | — | 28 (17–30) | 28.9 (28.2–29.6) | 28.1 (26.7–29.5) |
| Mild cognitive impairment, % (n) | — | 27 (30) | — | — | — | — | — |
|
| |||||||
| Comorbidities | |||||||
| Coronary artery disease, % (n) | — | 63 (71) | 55.4 (46) | 55.5 (15) | 73 (44) | 64 (14) | 50 (5) |
| Renal dysfunction, % (n) | 30.5 (11) | — | 16.9 (14) | — | 88 (53)a | 32 (7) | 10 (1) |
|
| |||||||
| Cardiovascular risk factors | |||||||
| Obesity, % (n) | — | — | 50.6 (42) | — | 88 (53) | 41 (9) | 0 (0) |
| Smoking, % (n) | — | 18 (20) | 21.7 (18) | 29.6 (8) | 2 (1) | 23 (5) | 20 (2) |
| Diabetes, % (n) | 30.5 (11) | 31 (35) | 30.1 (25) | 29.6 (8) | 25 (15) | 27 (6) | 40 (4) |
| Hypertension, % (n) | 88.9 (32) | 98 (109) | 97.6 (81) | 100 (27) | 75 (45) | 95 (21) | 90 (9) |
| Dyslipidemia, % (n) | 83.3 (30) | 81 (90) | 72.3 (60) | 74.1 (20) | 73 (44) | 86 (19) | 50 (5) |
n = number, TAVI = transcatheter aortic valve implantation, SD = standard deviation, ES = Edwards-SAPIEN, MCV = Medtronic CoreValve.
aRenal dysfunction indicated by estimated glomerular filtration rate <60 mL/min.