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Differential changes observed in the ER morphology of THP-1 cells 24 hrs after infections with either H37Ra or H37Rv. (a) H37Ra stimulates the smooth endoplasmic reticulum as shown in electron micrograph. (b) H37Rv induces the rough endoplasmic reticulum. (c) Electron micrograph of ER (microsomes) of uninfected THP-1 cells. Endoplasmic reticulum of panels (a), (b), and (c) was denoted as SER, RER, and ER, respectively (scale bar 500 nm).
