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. 2015 Feb 16;2015:106540. doi: 10.1155/2015/106540

Figure 2.

Figure 2

T-MSCs inhibit differentiation and maturation of DCs by secretion of soluble factors. (a) BMCs and T-MSCs were cultured in a transwell plate and BMCs were induced to differentiate into DCs by GM-CSF. (b) BMCs differentiation into CD11b+ cells was inhibited by T-MSCs added at day 0 (** P < 0.01). (c) CD86 expression on mature DCs was significantly downregulated by T-MSCs (** P < 0.01). Similar to the coculture condition, MHC class II expression on immature and mature DCs was inhibited by factors secreted from T-MSCs (** P < 0.01). CD14 expression by T-MSCs showed a trend toward increase, but it was not significant.