Skip to main content
. 2015 Feb 3;4(2):e225. doi: 10.1038/mtna.2014.76

Figure 3.

Figure 3

Histopathology and grip strength after systemic injections of the 10-vPMO cocktail. (a) Hematoxylin and eosin staining in the diaphragm (DIA), biceps femoris (BF), quadriceps (QUA), gastrocnemius (GC), and tibialis anterior (TA) 2 weeks after the last of nine systemic injections of 6 mg/kg 10-vPMO cocktail at 2-week intervals (9× i.v. vPMOs) compared with wild-type (WT) and nontreated (NT) muscles. Scale bar, 100 μm. (b) Significant reduction in percentage of centrally nucleated fibers in skeletal muscles after long-term systemic treatment (n = 4 in nontreated and n = 6–7 in treated group). (c) Detection of IgG (green) in DIA, BF, QUA and HRT muscles of WT, nontreated and treated mdx52 mice 2 weeks after the final injection. (d) Increased grip power (kilogram force/kg) of hind limb in mdx52 mice after eight administrations of the cocktail. Data (n = 5 in nontreated and n = 3 in treated group) are presented as mean ± SD. * P < 0.05 and ** P < 0.01.