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. 2015 Feb 17;4(2):e227. doi: 10.1038/mtna.2015.3

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Copyright © 2015 American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Model slopes of CD4/CD8 ratio in peripheral blood. The relative changes in CD4/CD8 ratio of sh1005- (EGFP+) and no-shRNA control- (mCherry+) modified CD4+ T lymphocytes in peripheral blood were compared using a linear mixed effects model by including all data from the three cohort experiments (Ex1, EX2 and EX3). CD4/CD8 ratio in shRNA-transduced cells (EGFP+, dotted line) and control cells (mCherry, solid line) overlayed on raw values (EGFP+, open circle; mCherry+, solid circle) were shown.