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. 2015 Feb 17;4(2):e227. doi: 10.1038/mtna.2015.3

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Copyright © 2015 American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Maintenance of CD4/CD8 ratio in sh1005-modified CD4+ T cells in lymphoid tissue. (a) Representative data for percentage of CD4 and CD8 expression in EGFP+ (top panels) and mCherry+ (bottom panels) CD3+ T lymphocytes in bone marrow (BM), spleen, lung, small and large intestine (SI and LI) and intraepithelial lymphocytes (IEL) and lamina propria lymphocytes (LPL) in a R5 tropic HIV-1_NFNSX–challenged hu BLT mice. CD4+ and CD8+ populations were gated and percentages are shown. (b) The data of CD4/CD8 ratio in EGFP+ CD3+ T lymphocytes (solid circle) and in mCherry+ lymphocytes (open circle) from all analyzed mice are shown. Samples were obtained between 8 and 12 weeks after HIV-1 challenge. A bar represents the mean value. **P ≤ 0.01. ***P ≤ 0.001. ****P ≤ 0.0001.