Table 1. Hematopoietic colonies derived from untreated or cocaine exposed CD34 + cells from either fetal liver, cord blood, or adult bone marrow. Donors 1–3 represent fetal liver, donors 4–6 represent cord blood, and donors 7–9 represent adult bone marrow. Values are the Mean and SEM. E, erythroid, M, macrophage, G, granulocyte, GM, mixed granulocyte-macrophage colonies.
| E | P value | M | P value | G | P value | GM | P value | Total | P value | |
|---|---|---|---|---|---|---|---|---|---|---|
| Donor 1 | 12.67 +/− 1.453 | 0.0023 | 23.67 +/− 6.848 | 0.0056 | 26.00 +/− 4.359 | 0.0206 | 22.67 +/− 2.333 | 0.0102 | 85.00 +/− 4.933 | 0.0008 |
| Cocaine | 2.333 +/− 0.333 | 7.00 +/− 1.155 | 8.667 +/− 1.667 | 10.67 +/− 1.202 | 26.67 +/− 3.712 | |||||
| Donor 2 | 16.67 +/− 3.283 | 0.0088 | 19.67 +/− 4.333 | 0.027 | 29.00 +/− 7.371 | 0.0752 | 20.67 +/− 2.028 | 0.0015 | 88.00 +/− 14.57 | 0.0088 |
| Cocaine | 0.6667 +/− 0.6667 | 4.000 +/− 1.528 | 9.667 +/− 3.333 | 3.000 +/− 1.528 | 17.33 +/− 2.667 | |||||
| Donor 3 | 1.333 +/− 0.6667 | 0.4216 | 6.000 +/− 0.5774 | 0.0005 | 21.33 +/− 4.702 | 0.015 | 5.667 +/− 3.844 | 3.469 | 34.33 +/− 8.0819 | 0.001 |
| Cocaine | 0.6667 +/− 0.3333 | 0.0 +/− 0.0 | 1.333 +/− 1.333 | 1.333 +/− 1.333 | 3.333 +/− 0.6667 | |||||
| Donor 4 | 22.33 +/− 3.390 | 0.0082 | 21.33 +/− 4.153 | 0.0059 | 44.67 +/− 10.88 | 0.001 | 23.67 +/− 2.102 | 0.001 | 112.0 +/− 6.557 | 0.0004 |
| Cocaine | 3.000 +/− 0.5774 | 6.667 +/− 2.333 | 7.667 +/− 2.404 | 2.667 +/− 2.186 | 20.0 +/− 5.508 | |||||
| Donor 5 | 22.67 +/− 8.344 | 0.0113 | 21.33 +/− 7.164 | 0.083 | 30.00 +/− 5.217 | 0.0024 | 23.00 +/− 5.132 | 0.065 | 97.00 +/− 6.658 | 0.0007 |
| Cocaine | 3.333 +/− 2028 | 10.00 +/− 1.528 | 11.00 +/− 1.155 | 9.333 +/− 1.202 | 33.33 +/− 1.333 | |||||
| Donor 6 | 14.00 +/− 1.732 | 0.0074 | 19.33 +/− 1.856 | 0.0011 | 21.33 +/− 4.910 | 0.0674 | 14.67 +/− 2.333 | 0.0269 | 69.33 +/− 9.871 | 0.0085 |
| Cocaine | 2.667 +/− 1.453 | 3.333 +/− 0.3333 | 8.333 +/− 1.764 | 6.000 +/− 1.000 | 20.33 +/− 2.333 | |||||
| Donor 7 | 9.667 +/− 2.603 | 0.3164 | 15.00 +/− 4.041 | 0.0849 | 8.333 +/− 1.667 | 0.0354 | 14.67 +/− 1.453 | 0.0101 | 51.00 +/− 6.083 | 0.0096 |
| Cocaine | 5.667 +/− 2.333 | 5.667 +/− 0.6667 | 2.000 +/− 1.155 | 7.333 +/− 0.6667 | 20.67 +/− 2.333 | |||||
| Donor 8 | 12.33 +/− 4.333 | 0.0939 | 13.67 +/− 2.728 | 0.0387 | 7.00 +/− 1.155 | 0.0214 | 13.67 +/− 1.856 | 0.0154 | 47.00 +/− 7.506 | 0.0142 |
| Cocaine | 2.333 +/− 1.453 | 5.333 +/− 0.333 | 1.667 +/− 0.882 | 5.667 +/− 0.6667 | 14.67 +/− 2.028 | |||||
| Donor 9 | 3.00 +/− 2.082 | 0.223 | 10.67 +/− 1.202 | 0.002 | 6.00 +/− 2.00 | 0.04 | 13.33 +/− 3.528 | 0.091 | 33.00 +/− 4.359 | 0.005 |
| Cocaine | 0.00 +/− 0.00 | 0.667 +/− 0.667 | 0.00 +/− 0.00 | 4.00 +/− 2.309 | 4.667 +/− 2.404 |