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. 2015 Mar 2;5:8667. doi: 10.1038/srep08667

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Individuals were familiarized with novel objects for 2 hours in a massed paradigm. Individuals were moved to a fresh media without treatment for 23 hours, after which MK-801 was administered. Reintroduction of the objects occurred 1 hour after MK-801 administration. Controls have a significant RES preference at T0 (t = 2.00, p = 0.051), T2 (t = 3.44, p = 0.022) and T3 (t = 4.26, p = 0.023). MK-801-treated individuals displayed RES preference at T2 (t = 3.23, p = 0.012) and T3 (t = 3.47, p = 0.003). Significance *p < 0.05, **p < 0.001, ***p < 0.0001, computed using single sample t-test tested against 50%. For control and MK-801 treated groups, n = 36. Error bars indicate SEM.