Developmental exposure of male offspring to endosulfan significantly reduces the expression of DAT, TH, VMAT2, and D2 receptor in the frontal cortex. Female mice were administered either 0 (control) or 1 mg/kg endosulfan throughout gestation and lactation. Expression of DAT (A), TH (B), VMAT2 (C), D2 receptor (D) in the frontal cortex was determined by immunoblot in male offspring. Representative immunoblot (E) images for DAT, TH, VMAT2, and D2 receptor are included. Data represent mean ± SEM (6–8 animals each from a different litter per treatment group). *Values for animals that are significantly different from controls (p < 0.05). **Values for animals that are significantly different from controls (p < 0.01).