Table 2.

Effect of combining the exonuclease and active site mutations in DNA polymerase ε on mutation rates in diploids. Mismatch repair proficient strains

Relevant mutation	His+ reversion rate (× 10-8)	Fold increase
+/+	0.5	1
	0.3–1.2
+/ pol2-Y831A	1.1	2.2
	0.7–1.7
pol2-Y831A/ pol2-Y831A	2.2	4.4
	1.8–5.7
+/pol2-4	3.8	7.6
	2.6–4.7
pol2-4/pol2-4	26	52
	16–45
pol2-4/ pol2-Y831A	28	56
	16–53
pol2-4/ pol2-4,Y831A	21	42
	18–34
pol2-Y831A/ pol2-4,Y831A	1.8	3.6
	1.2–3.1
pol2-4,Y831A/pol2-4,Y831A	1.8	3.6
	1.1–2.3