Table 3.

Effect of combining the exonuclease and active site mutations in DNA polymerase ε on mutation rates in diploids. Mismatch repair deficient strains (pms1/pms1)

Relevant mutation	His+ reversion rate (× 10-8)	Fold increase
+/+	110	1
	90–140
+/pol2-Y831A	400	4
	270–600
pol2-Y831A/pol2-Y831A	820	7
	750–950
+/pol2-4	1,500	14
	930–3600
pol2-4/pol2-4	9,400	85
	5,900–14,000
pol2-4/ pol2-Y831A	8,400	76
	3,500–17,000
+/pol2-4,Y831A	210	2
	180–270
pol2-4/pol2-4,Y831A	11,000	100
	8,100–22,000
pol2-Y831A/pol2-4,Y831A	1,200	11
	1,030–1,460
pol2-4,Y831A/pol2-4,Y831A	1,020	9
	840–2,300