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. 2004 May 26;2:11. doi: 10.1186/1741-7007-2-11

Table 4.

Effect of combining the mutation in the exonuclease domain of the Pol δ gene with the active site mutation in Pol ε genes on mutation rates in mismatch repair-proficient derivatives of 8C-YUNI101 strain

Relevant genotype Mutation rates for different markers
Forward mutation Reversion

Canr × (10-7) Base substitutions Ura+ (× 10-8) Frameshifts (+1) His+ (× 10-8)

wild-type 2.9 1.5 1.5
1.6–4.9 1.1–2.3 1.2–2.1
+/pol3-01* 28 n/a 33
22–28 31–39
+/pol3-01*pol2-Y831A 31 n/a 27
25–39 24–34
pol3-01 190 19 110
140–260 6–35 80–160
pol3-01 pol2-Y831A 130 14 34
90–210 13–28 18–43

n/a, non applicable, since these strains are Ura+. *Haploids with duplication of the POL3 gene.