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. Author manuscript; available in PMC: 2015 Mar 2.
Published in final edited form as: Nat Immunol. 2014 Feb;15(2):118–127. doi: 10.1038/ni.2787

Table 1.

Analysis and visualization tools for systems immunology

Data types or tools Program name Weblink
TCR repertoire MiTCR36 http://mitcr.milaboratory.com/
Decombinator101 https://github.com/uclinfectionimmunity/Decombinator
iSSAKE102 ftp://ftp.bcgsc.ca/supplementary/iSSAKE/
IMGT or HIGHV-Quest37 http://www.imgt.org/HighV-QUEST/
Antibody repertoire IMGT or HIGHV-Quest37 http://www.imgt.org/HighV-QUEST/
IgTree103 http://immsilico2.lnx.biu.ac.il/Software.html
VDJFasta104 http://sourceforge.net/projects/vdjfasta/
RNA-seq105 VarScan106 http://varscan.sourceforge.net/
GATK107 http://www.broadinstitute.org/gatk/
SAMtools108 http://samtools.sourceforge.net/
ERANGE40 http://woldlab.caltech.edu/rnaseq
Scripture109 http://www.broadinstitute.org/software/scripture/
Cufflinks45 http://cufflinks.cbcb.umd.edu/
CuffDiff45 http://cufflinks.cbcb.umd.edu/
EdgeR46 http://www.bioconductor.org/packages/2.12/bioc/html/edgeR.html
DESeq49 http://www.bioconductor.org/packages/release/bioc/html/DESeq.html
Myrna110 http://bowtie-bio.sourceforge.net/myrna/index.shtml
PoissonSeq48 http://cran.r-project.org/web/packages/PoissonSeq/index.html
ChIP-seq105,111 ERANGE40 http://woldlab.caltech.edu/rnaseq
CisGenome112 http://www.biostat.jhsph.edu/~hji/cisgenome/
MACS113 http://liulab.dfci.harvard.edu/MACS/
PeakSeq114 http://info.gersteinlab.org/PeakSeq/
SPP115 http://compbio.med.harvard.edu/Supplements/ChIP-seq/
eQTL MatrixEQTL58 http://www.bios.unc.edu/research/genomic_software/Matrix_eQTL/
PLINK116 http://pngu.mgh.harvard.edu/~purcell/plink/
R/qtl117 http://www.rqtl.org/
snpMatrix118 http://www.bioconductor.org/packages/2.3/bioc/html/snpMatrix.html
Networks WGCNA82 http://labs.genetics.ucla.edu/horvath/CoexpressionNetwork/Rpackages/WGCNA/
coXpress119 http://coxpress.sourceforge.net/
Inferelator120 http://bonneaulab.bio.nyu.edu/networks.html
ARACNE121 http://wiki.c2b2.columbia.edu/workbench/index.php/ARACNe/
RimbaNET87 http://icahn.mssm.edu/departments-and-institutes/genomics/about/software/rimbanet/
Cytometry63 FlowMeans122 http://www.bioconductor.org/packages/release/bioc/html/flowMeans.html
FLAME123 http://www.broadinstitute.org/cancer/software/genepattern/modules/FLAME/
FLOCK124 https://immport.niaid.nih.gov/immportWeb/analysis/flow/displayOverview.do?method=displayFlockOverview
SamSPECTRAL125 http://www.bioconductor.org/packages/devel/bioc/html/SamSPECTRAL.html
SPADE64 http://www.bioconductor.org/packages/release/bioc/html/spade.html
http://cytospade.org/
viSNE66 http://www.c2b2.columbia.edu/danapeerlab/html/cyt.html
Visualization Cytoscape93 http://www.cytoscape.org/
Gephi https://gephi.org/
Circos126 http://circos.ca/
Databases or online tools ImMunoGeneTics127 http://www.imgt.org/
ImmPort https://immport.niaid.nih.gov/
MsigDB53 http://www.broadinstitute.org/gsea/msigdb/index.jsp
GenePattern54 http://www.broadinstitute.org/cancer/software/genepattern/
DAVID55,56 http://david.abcc.ncifcrf.gov/
Stanford Data Miner128
Structure129 http://pritchardlab.stanford.edu/structure.html
PCAdmix https://sites.google.com/site/pcadmix/home
myPEG130 http://www.megasoftware.net/myPEG/myPEG.php
GWASdb131 http://jjwanglab.org/gwasdb/
HaploReg132 http://www.broadinstitute.org/mammals/haploreg/haploreg.php
RegulomeDB133 http://regulomedb.org/
GRAIL134 http://www.broadinstitute.org/mpg/grail/
DGIdb135 http://dgidb.genome.wustl.edu/
GSEA50 http://www.broadinstitute.org/gsea/index.jsp
ProfileChaser136 http://profilechaser.stanford.edu/
LINCS browser137,138 http://lincs.hms.harvard.edu/explore/pathway/
http://lincs.hms.harvard.edu/explore_/canvasbrowser/