Figure 7.

Junction dynamics. (a) Illustration and differential equations for a simple model, which represents junction formation between two cells. The cells can be either bound or unbound. The transition from the unbound state to the bound state has probability p and from the bound state to the unbound state probability q. (b) Probability of the bound state over time if the cells are initially unbound at two different time scales ((i) 60 s; (ii) 15 min). (c) Probability of the bound state over time if the cells are initially bound. (b,c) The curves represent the solutions of the differential equations for the parameters p and q, which are determined by the best-fit parameters for spheroid formation of L cells expressing WT-N-cadherin (p = 0.75, q = 0.01), V81D/V174D (p = 0.65, q = 0.1), R14E (p = 0.75, q = 0.1) and W2A (p = 0.05, q = 0.01) (see also figure 4).