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Concentration dependence of the aggregation of p53 core domain Y220C in stabilized quadruple mutant construct (QCYC). (A and B) Hyperbolic concentration dependence of QCYC at low protein concentrations. (C) Concentration dependence of initial aggregation rate measured directly from initial rates. (D) Concentration dependence of initial aggregation rate calculated from k1 and k2 for first-order consecutive reactions.
