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Decrease of brain volume may induce an increase of neuron density. Pathological factors including: 1. smaller cell bodies, 2. decrease neurites, 3. shortening of dendrites, and 4. A decrease in presynaptic terminals, is considered to induce volume decrease (modified from Selemon et al., 1995,43 Glantz et al., 2000,44 and Glantz et al., 200645).
