Table 3.
Reports of abnormality in synaptic associate protein/neurite in schizophrenic brain
| Area | Fimdings | Reporter |
|---|---|---|
| Hippocampal temporolimbic | Decrease of MAP2/5 in hippocampal dendrite | Arnold, 1991b46 |
| Decrease of Synapsin in hippocampus | Browning, 199347 | |
| Decrease of Synaptophysinin hippocampus | Eastwood, 199548 | |
| Decrease of Complexin I and II | Harisson/Eastwood, 199849 | |
| Decrease of SNAP | Young, 199850 | |
| Decrease of Complexin I and II | Eastwood/Harrison, 200051 | |
| Decrease of Dysbindin1in subiculm | Talbot, 200452 | |
| Decrease of VGLUT1mRNAin hippocampus | Eastwood/Harrison, 200553 | |
| Decrease of the ratio of ComplexinI/ComplexinII | Sawada, 200554 | |
| Decrease of spine in CA3 of schizophrenia (electron microscopic) | Kolomeets, 200555 | |
| Frontal lobe | Decrease of NE positive-vertical fiber | Benes, 1987b19 |
| Decrease of density of synapse | Aganova/Uranova, 199256 | |
| Decrease of Synaptphysin in BA9,10,20 | Perrone-Bizzozero, 199657 | |
| Changes of distribution of TH-positive fiber | Benes, 199758 | |
| Increase of Synaptophysin, SNAP-25, Syntaxin in BA24 | Gabriel, 199759 | |
| Increase of Syntaxin in BA24 | Honer, 199760 | |
| Decrease of Synaptophysin in BA9,46 | Glanz/Lewis, 199761 | |
| Decrease of neurites of Pyramydal neuron | Garey, 199862 | |
| Decrease of SNAP-25in BA10,20/Increase in BA9 | Thompson, 199863 | |
| Selective decrease of GABAnergic nerve ending GABA | Woo, 199864 | |
| Decrease of Synaptophysin, SNAP-25 in BA10 | Karson, 199965 | |
| Decrease of Synaptophysin, Myelin basic protein in prefrontal cortex | Honer, 199966 | |
| Decrease density of GAT-1-positive neuron in Layer II-III of coretx | Pierri, 199967 | |
| Decrease expression of PSD95 in BA9 | Ohnuma, 200068 | |
| Increase of GAD65-immunoreactivity in Layer II-III of cortex | Benes, 200069 | |
| Increase of GABA(A)-receptor in BA46 | Volk, 200270 | |
| Decrease of SAP97 | Toyooka, 200271 | |
| Decrease of VAMP | Halim, 200372 | |
| Decrease of GABA membrane transporter1in BA46 | Konopaske, 200673 |
MAP: microtubule associated protein, SNAP: Synaptosoal associated protein, BA: Brodmann Area, NF: neurofilament, TH: Tyrosin Hydroxilase, GAT1: GABA membrane transporter1, PSD: Postsynaptic density protein95, GAD: Glutamate decarboxylase, VAMP: Vesicle associated Membrane protein