| Problems in neuropathological study of schizophrenia |
| 1. Small brain samples with precise clinical information |
| 2. Inhomogeneous brain tissue situation (brain tissue influenced by agonal factors (anoxic, infection etc.), post-mortem interval time, or differences of tissue fixation etc.) |
| 3. Difficulty of definding normal brain structure for schizophrenia |
| 4. Difficulty in interpreting abnormal findings (Is it a primary change or secondary/tertiary change?) |
| 5. Discordance between brain histopathology and symptomatological clinical diagnosis |
