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. 2014 Feb;76(1-2):59–72.

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This is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4 — Cardiac fibrosis and expression of collagen genes in the left ventricle of DS rats in the five experimental groups at 11 weeks of age. (A) Collagen deposition as revealed by Azan-Mallory staining in perivascular (upper panels) or interstitial (lower panels) regions of the LV myocardium. Scale bars, 200 µm. (B, C) Relative extents of perivascular and interstitial fibrosis, respectively, in the LV myocardium as determined from sections similar to those in (A). (D) Ratio of the amount of collagen type I mRNA to that of collagen type III mRNA. Data in (B) through (D) are means ± SEM for animals in each group. *P < 0.05 versus CONT group; †P < 0.05 versus LVH group; ‡P < 0.05 versus ADX+V group; §P < 0.05 versus ADX+CTC group.