Table 4.

Maximal responses to ACh-induced relaxation in MA from control and db/db mice incubated with vehicle or aldosterone in the presence or absence of MR and GPER antagonists, eplerenone and G15, respectively.

Groups	Control	db/db
Vehicle	98.25 ± 0.7 (n = 7)	93.3 ± 3.8 (n = 6)
Aldosterone (10 nM)	84.6 ± 2.7 (n = 5) *	89.1 ± 5.5 (n = 5)*
Eplerenone (10 μM)	90.9 ± 5.0 (n = 4)	87.9 ± 0.6 (n = 5)*
Eplerenone (10 μM) + aldosterone (10 nM)	96.4 ± 0.6 (n = 5) #	87.7 ± 7.4 (n = 5)
G15 (1 μM)	93.0 ± 1.1 (n = 5)	76.5 ± 7.3 (n = 5)
G15 (1 μM) + aldosterone (10 nM)	87.8 ± 6.0 (n = 4)	82.2 ± 5.8 (n = 5)*

The values show % of PhE-induced pre-contraction. The data represent the mean ± SEM of n experiments. One-way ANOVA with Bonferroni post-test (p < 0.05). (*), (#) vs. Vehicle and aldosterone, respectively.