Table 1.
Platelet receptors, their ligands, and their target structure contributing to vascular inflammation.
| Receptor | Ligand | Interaction with |
|---|---|---|
| PSGL-1 | P-Selectin | Endothelial cells (Frenette et al., 2000) |
| P-Selectin | PSGL-1 | Leukocytes (Dole et al., 2007) |
| GPIbα | Mac 1 P-Selectin | Leukocytes (Gawaz et al., 1997) Endothelial cells (Massberg et al., 2002) |
| GPIIb-IIIa (αIIbβ3) | Mac 1 Fibrinogen, vWF | Leukocytes (Weber and Springer, 1997) Vessel wall (Bombeli et al., 1998) |
| α5β1, α6β1 | Subendothelial extracellular matrix | Damaged vessel wall (Gruner et al., 2003) |
| α2β1 | Collagen | Damaged vessel wall (Inoue et al., 2003) |
| αVβ3 | Vitronectin | Endothelial cells (Gawaz et al., 1997) |
| CX3CR1 | CX3CL1 | Endothelial cells (Schulz et al., 2007) |
| ICAM-2 | LFA-1 | Leukocytes(Weber et al., 2004) |
| JAM-A | JAM-A | Vessel wall (Karshovska et al., 2015) |
| JAM-C | MAC-1 | Dendritic cells (Langer et al., 2007) |
| GPVI | Collagen | Damaged vessel wall (Massberg et al., 2003) |