Table 2.

Prevalence of rare variants (minor allele frequency ≤0.2%) in the eight main sarcomere genes

Gene	Number of cases	Percentage of sarcomere-positive individuals (N=383)	Percentage of the total cohort (N=874)
ACTC1	3	0.8	0.3
MYBPC3	191	49.9	21.9
MYH7	99	25.9	11.3
MYL2	6	1.6	0.7
MYL3	4	1.0	0.5
TNNI3	15	3.9	1.7
TNNT2	20	5.2	2.3
TPM1	8	2.1	0.9
Multiple	37	9.7	4.2
Total	383	100	43.8

The number and proportion of individuals for each individual gene excludes patients carrying more than one variant who are grouped under ‘multiple’.