Table 1.
Demographic and clinical characteristics of ADPKD and non-ADPKD matched controla population
| Group | Age Mean (SD) |
Age ≥65 years n (%) |
Female n (%) |
High risk for early progression n (%) |
Diabetes, n (%) |
CAD, n (%) |
Heart failure n (%) |
Hypertension n (%) |
Neoplasms n (%) |
|---|---|---|---|---|---|---|---|---|---|
| ADPKD stage 1 CKD (n=316) |
43.4 (16.0) | 18 (5.7) | 195 (61.7) | 133 (42.1) | 16 (5.1) | 28 (8.9) | 12 (3.8) | 198 (62.7) | 78 (24.7) |
| Non-ADPKD matched controls (n=1,580) |
43.2 (16.7) | 111 (7.0) | 975 (61.7) | N/A | 102 (6.5) | 62 (3.9) | 15 (0.9) | 243 (15.4) | 151 (9.6) |
| ADPKD stage 2 CKD (n=404) |
46.7 (12.2) | 17 (4.2) | 220 (54.5) | 219 (54.2) | 40 (9.9) | 56 (13.9) | 11 (2.7) | 301 (74.5) | 108 (26.7) |
| Non-ADPKD matched controls (n=2,020) |
46.60 (13.8) | 133 (6.6) | 1,100 (54.5) | N/A | 123 (6.1) | 71 (3.5) | 19 (0.9) | 294 (14.6) | 199 (9.9) |
| ADPKD stage 3 CKD (n=860) |
52.5 (12.5) | 104 (12.1) | 397 (46.2) | 508 (59.1) | 132 (15.3) | 156 (18.1) | 53 (6.2) | 682 (79.3) | 212 (24.7) |
| Non-ADPKD matched controls (n=4,300) |
52.42 (13.3) | 610 (14.2) | 1,985 (46.2) | N/A | 349 (8.1) | 248 (5.8) | 72 (1.7) | 854 (19.9) | 514 (12.0) |
| ADPKD stage 4 CKD (n=611) |
54.9 (12.5) | 102 (16.7) | 296 (48.4) | 358 (58.6) | 108 (17.7) | 124 (20.3) | 54 (8.8) | 505 (82.7) | 158 (25.9) |
| Non-ADPKD matched controls (n=3,055) |
54.8 (13.2) | 587 (19.2) | 1,480 (48.4) | N/A | 279 (9.1) | 212 (6.9) | 64 (2.1) | 648 (21.2) | 395 (12.9) |
| ADPKD stage 5 CKD (n=842) |
55.2 (11.5) | 141 (16.7) | 378 (44.9) | 504 (59.9) | 151 (17.9) | 220 (26.1) | 104 (12.4) | 734 (87.2) | 259 (30.8) |
| Non-ADPKD matched controls (n=4,210) |
55.4 (12.4) | 806 (19.1) | 1,890 (44.9) | N/A | 407 (9.7) | 291 (6.9) | 78 (1.9) | 937 (22.3) | 521 (12.4) |
| ADPKD dialysis (n=586) |
55.8 (11.4) | 104 (17.7) | 250 (42.7) | 329 (56.1) | 102 (17.4) | 162 (27.6) | 89 (15.2) | 524 (89.4) | 184 (31.4) |
| Non-ADPKD matched controls (n=2,930) |
56.0 (12.3) | 592 (20.2) | 1,250 (42.7) | N/A | 307 (10.5) | 200 (6.8) | 49 (1.7) | 668 (22.8) | 363 (12.4) |
| ADPKD post- transplant (n=615) |
53.3 (10.0) | 54 (8.8) | 267 (43.4) | 381 (62.0) | 117 (19.0) | 133 (21.6) | 50 (8.1) | 505 (82.1) | 215 (35.0) |
| Non-ADPKD matched controls (n=3,075) |
53.8 (11.4) | 360 (11.7) | 1,335 (43.4) | N/A | 297 (9.7) | 147 (4.8) | 33 (1.1) | 614 (20.0) | 392 (12.7) |
Notes:
a
ADPKD patients were grouped by CKD stage and matched by age and sex to a control population without ADPKD. Less than 1.0% of all non-ADPKD matched control patients had a diagnosis for CKD, procedure for dialysis, or an indicator for post-transplant.
Abbreviations: ADPKD, autosomal dominant polycystic kidney disease; CAD, coronary artery disease; CKD, chronic kidney disease; N/A, not available; SD, standard deviation.