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(A) Mean (± SD) selisistat AUC0–24 (μm h) following single doses between 5 and 600 mg in males (•) and females (
). The dashed line represents the NOAEL exposure. (B) Mean (± SD) selisistat AUC(0,24 h) (μm h) following repeated doses between 100 and 300 mg once daily in males (•) and females (
). The dashed line represents the NOAEL exposure
