Table 4.
Genes differentially modulated by selisistat in healthy volunteers
| Microarray results | |||
|---|---|---|---|
| Affymetrix ID | Symbol | Gene name | RT-qPCR results |
| 1553395_a_at | CD200R1 | CD200 receptor 1 | Discarded |
| 220384_at | TXNDC3 | thioredoxin domain containing 3 | Validated |
| 224310_s_at | BCL11B | B-cell CLL/lymphoma 11B | Discarded |
| 222562_s_at | TNKS2 | tankyrase | Discarded |
| 200603_at | PRKAR1A | protein kinase cAMP-dep. Regulatory, I alpha | Validated |
| 209160_at | AKR1C3 | aldo-keto reductase 1-C3 | Validated |
| 209137_s_at | USP10 | ubiquitin specific peptidase10 | Validated |
| 206643_at | HAL | histidine ammonia-lyase | Discarded |
| 200907_s_at | PALLD | palladin, cytoskeletal associated protein | Validated |
| 235146_at | TMCC3 | transmembrane and coiled coil domains 3 | Validated |
| 223080_at | GLS | glutaminase | Not tested (a) |
| 214321_at | NOV | ? | Not tested (a) |
| 206942_s_at | PMCH | pro-melanin-concentrating hormone | Discarded |
| 228624_at | TMEM144 | transmembrane protein 144 | Discarded |
| 240757_at | CLASP1 | cytoplasmic linker associated protein 1 | Not tested (b) |
| 216102_at | PHLDB1 | pleckstrin homology-like domain, B-1 | Not tested (b) |
| 202323_s_at | ACBD3 | acyl-CoA binding domain containing 3 | Validated |
| 204893_s_at | ZFYVE9 | zinc finger, FYVE domain containing 9 | Discarded |
| 219529_at | CLIC3 | chloride intracellular channel 3 | Validated |
| 217863_at | PIAS1 | protein inhibitor of activated STAT1 | not tested (b) |
| 202067_s_at | LDLR | low density lipoprotein receptor | Validated |
| 223849_s_at | MOV10 | Moloney leukemia virus 10 homolog | Discarded |
| 1555766_a_at | GNG2 | guanine nucleotide binding protein, gamma 2 | Discarded |
The table reports the selected probe set and the corresponding gene name. The RT-qPCR column reports genes for which the modulation observed in the microarray was confirmed as ‘Validated’. Five genes were not tested because the Affymetrix ID recognized ambigous targets, indicated in table with (a) or a low annotation grade, indicated with (b).