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. 2015 Feb 20;10:1463–1477. doi: 10.2147/IJN.S76114

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© 2015 Guo et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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NO/NOS systemic disorder and downregulated ET-1 mRNA expression mediated by SiNP exposure in HUVECs.

Notes: *P<0.05 versus control. Data presented as means ± SD, n=3. (A) Release of NO after SiNP exposure for 24 hours in HUVECs. (B) Real-time PCR assessment of mRNA levels for eNOS, iNOS, and ET-1 normalized to β-actin in HUVECs after 24 hours’ SiNP treatment.

Abbreviations: eNOS, endothelial nitric oxide synthase; iNOS, inducible NOS; SiNP, silica nanoparticle; HUVECs, human umbilical vein endothelial cells; SD, standard deviation; ET-1, endostatin 1; PCR, polymerase chain reaction; mRNA, messenger ribonucleic acid.